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Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and apoptosis in breast and prostate tumor cells.
de Sousa IH, Campos VNS, Vale AAM, Maciel-Silva VL, Leite CM, Lopes AJO, Mourão PS, das Chagas Alves Lima F, Batista AA, de Azevedo Dos Santos APS, Almeida MAP, Pereira SRF. de Sousa IH, et al. Among authors: campos vns. Toxicol In Vitro. 2020 Feb;62:104679. doi: 10.1016/j.tiv.2019.104679. Epub 2019 Oct 30. Toxicol In Vitro. 2020. PMID: 31676337