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Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives.
Gomez-Monterrey I, Campiglia P, Carotenuto A, Califano D, Pisano C, Vesci L, Lama T, Bertamino A, Sala M, di Bosco AM, Grieco P, Novellino E. Gomez-Monterrey I, et al. Among authors: campiglia p. J Med Chem. 2007 Apr 19;50(8):1787-98. doi: 10.1021/jm0612158. Epub 2007 Mar 22. J Med Chem. 2007. PMID: 17375902
Spiro[(dihydropyrazin-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)]-based cytotoxic agents: structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain.
Gomez-Monterrey I, Campiglia P, Carotenuto A, Stiuso P, Bertamino A, Sala M, Aquino C, Grieco P, Morello S, Pinto A, Ianelli P, Novellino E. Gomez-Monterrey I, et al. Among authors: campiglia p. J Med Chem. 2008 May 22;51(10):2924-32. doi: 10.1021/jm7013056. Epub 2008 Apr 23. J Med Chem. 2008. PMID: 18429610
Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase.
Cipolletta E, Monaco S, Maione AS, Vitiello L, Campiglia P, Pastore L, Franchini C, Novellino E, Limongelli V, Bayer KU, Means AR, Rossi G, Trimarco B, Iaccarino G, Illario M. Cipolletta E, et al. Among authors: campiglia p. Endocrinology. 2010 Jun;151(6):2747-59. doi: 10.1210/en.2009-1248. Epub 2010 Apr 14. Endocrinology. 2010. PMID: 20392834 Free PMC article.
A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells.
Gomez-Monterrey I, Campiglia P, Bertamino A, Aquino C, Sala M, Grieco P, Dicitore A, Vanacore D, Porta A, Maresca B, Novellino E, Stiuso P. Gomez-Monterrey I, et al. Among authors: campiglia p. Br J Pharmacol. 2010 Jun;160(4):931-40. doi: 10.1111/j.1476-5381.2010.00718.x. Br J Pharmacol. 2010. PMID: 20590589 Free PMC article.
Heat shock protein 90 inhibitors as therapeutic agents.
Gomez-Monterrey I, Sala M, Musella S, Campiglia P. Gomez-Monterrey I, et al. Among authors: campiglia p. Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):313-36. doi: 10.2174/157489212801820066. Recent Pat Anticancer Drug Discov. 2012. PMID: 22338602 Review.
Characterization of a selective CaMKII peptide inhibitor.
Gomez-Monterrey I, Sala M, Rusciano MR, Monaco S, Maione AS, Iaccarino G, Tortorella P, D'Ursi AM, Scrima M, Carotenuto A, De Rosa G, Bertamino A, Vernieri E, Grieco P, Novellino E, Illario M, Campiglia P. Gomez-Monterrey I, et al. Among authors: campiglia p. Eur J Med Chem. 2013 Apr;62:425-34. doi: 10.1016/j.ejmech.2012.12.053. Epub 2013 Jan 22. Eur J Med Chem. 2013. PMID: 23395965
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