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Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses.
Jaynes JM, Sable R, Ronzetti M, Bautista W, Knotts Z, Abisoye-Ogunniyan A, Li D, Calvo R, Dashnyam M, Singh A, Guerin T, White J, Ravichandran S, Kumar P, Talsania K, Chen V, Ghebremedhin A, Karanam B, Bin Salam A, Amin R, Odzorig T, Aiken T, Nguyen V, Bian Y, Zarif JC, de Groot AE, Mehta M, Fan L, Hu X, Simeonov A, Pate N, Abu-Asab M, Ferrer M, Southall N, Ock CY, Zhao Y, Lopez H, Kozlov S, de Val N, Yates CC, Baljinnyam B, Marugan J, Rudloff U. Jaynes JM, et al. Among authors: calvo r. Sci Transl Med. 2020 Feb 12;12(530):eaax6337. doi: 10.1126/scitranslmed.aax6337. Sci Transl Med. 2020. PMID: 32051227 Free PMC article.
Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels.
Zhang X, Chen W, Li P, Calvo R, Southall N, Hu X, Bryant-Genevier M, Feng X, Geng Q, Gao C, Yang M, Tang K, Ferrer M, Marugan JJ, Xu H. Zhang X, et al. Among authors: calvo r. Elife. 2019 Dec 11;8:e51423. doi: 10.7554/eLife.51423. Elife. 2019. PMID: 31825310 Free PMC article.
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction.
Chen FW, Davies JP, Calvo R, Chaudhari J, Dolios G, Taylor MK, Patnaik S, Dehdashti J, Mull R, Dranchack P, Wang A, Xu X, Hughes E, Southall N, Ferrer M, Wang R, Marugan JJ, Ioannou YA. Chen FW, et al. Among authors: calvo r. iScience. 2022 Aug 14;25(9):104941. doi: 10.1016/j.isci.2022.104941. eCollection 2022 Sep 16. iScience. 2022. PMID: 36065186 Free PMC article.
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. Zhang X, et al. Among authors: calvo r. Nat Commun. 2016 Jun 30;7:12109. doi: 10.1038/ncomms12109. Nat Commun. 2016. PMID: 27357649 Free PMC article.
Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.
Yu L, Zhang X, Yang Y, Li D, Tang K, Zhao Z, He W, Wang C, Sahoo N, Converso-Baran K, Davis CS, Brooks SV, Bigot A, Calvo R, Martinez NJ, Southall N, Hu X, Marugan J, Ferrer M, Xu H. Yu L, et al. Among authors: calvo r. Sci Adv. 2020 Feb 7;6(6):eaaz2736. doi: 10.1126/sciadv.aaz2736. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128386 Free PMC article.
Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.
Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, Calvo R, Patnaik S, Wang W, King G, Samie M, Gao Q, Sahoo S, Sundaresan S, Keeley TM, Wang Y, Marugan J, Ferrer M, Samuelson LC, Merchant JL, Xu H. Sahoo N, et al. Among authors: calvo r. Dev Cell. 2017 May 8;41(3):262-273.e6. doi: 10.1016/j.devcel.2017.04.003. Dev Cell. 2017. PMID: 28486130 Free PMC article.
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.
Parks DJ, LaFrance LV, Calvo RR, Milkiewicz KL, Marugán JJ, Raboisson P, Schubert C, Koblish HK, Zhao S, Franks CF, Lattanze J, Carver TE, Cummings MD, Maguire D, Grasberger BL, Maroney AC, Lu T. Parks DJ, et al. Among authors: calvo rr. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3310-4. doi: 10.1016/j.bmcl.2006.03.055. Epub 2006 Apr 4. Bioorg Med Chem Lett. 2006. PMID: 16600594
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.
Marugan JJ, Leonard K, Raboisson P, Gushue JM, Calvo R, Koblish HK, Lattanze J, Zhao S, Cummings MD, Player MR, Schubert C, Maroney AC, Lu T. Marugan JJ, et al. Among authors: calvo r. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3115-20. doi: 10.1016/j.bmcl.2006.03.067. Epub 2006 Apr 21. Bioorg Med Chem Lett. 2006. PMID: 16630722
609 results