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Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi.
Lechuga GC, Borges JC, Calvet CM, de Araújo HP, Zuma AA, do Nascimento SB, Motta MCM, Bernardino AMR, Pereira MCS, Bourguignon SC. Lechuga GC, et al. Among authors: calvet cm. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):154-164. doi: 10.1016/j.ijpddr.2016.07.001. Epub 2016 Jul 14. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27490082 Free PMC article.
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. Calvet CM, et al. PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006132. doi: 10.1371/journal.pntd.0006132. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29281643 Free PMC article.
30 results