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The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance.
Lawson M, Cureton N, Ros S, Cheraghchi-Bashi A, Urosevic J, D'Arcy S, Delpuech O, DuPont M, Fisher DI, Gangl ET, Lewis H, Trueman D, Wali N, Williamson SC, Moss J, Montaudon E, Derrien H, Marangoni E, Miragaia RJ, Gagrica S, Morentin-Gutierrez P, Moss TA, Maglennon G, Sutton D, Polanski R, Rosen A, Cairns J, Zhang P, Sánchez-Guixé M, Serra V, Critchlow SE, Scott JS, Lindemann JPO, Barry ST, Klinowska T, Morrow CJ, Carnevalli LS. Lawson M, et al. Among authors: cairns j. Cancer Res. 2023 Dec 1;83(23):3989-4004. doi: 10.1158/0008-5472.CAN-23-0694. Cancer Res. 2023. PMID: 37725704 Free PMC article.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Fok JHL, Ramos-Montoya A, Vazquez-Chantada M, Wijnhoven PWG, Follia V, James N, Farrington PM, Karmokar A, Willis SE, Cairns J, Nikkilä J, Beattie D, Lamont GM, Finlay MRV, Wilson J, Smith A, O'Connor LO, Ling S, Fawell SE, O'Connor MJ, Hollingsworth SJ, Dean E, Goldberg FW, Davies BR, Cadogan EB. Fok JHL, et al. Among authors: cairns j. Nat Commun. 2019 Nov 7;10(1):5065. doi: 10.1038/s41467-019-12836-9. Nat Commun. 2019. PMID: 31699977 Free PMC article.
High-Throughput Mechanism of Inhibition.
Davies G, Semple H, McCandless M, Cairns J, Holdgate GA. Davies G, et al. Among authors: cairns j. SLAS Discov. 2021 Feb;26(2):248-256. doi: 10.1177/2472555220983809. SLAS Discov. 2021. PMID: 33482076 Free article.
Genetic gains in early maturing maize hybrids developed by the International Maize and Wheat Improvement Center in Southern Africa during 2000-2018.
Tarekegne A, Wegary D, Cairns JE, Zaman-Allah M, Beyene Y, Negera D, Teklewold A, Tesfaye K, Jumbo MB, Das B, Nhamucho EJ, Simpasa K, Kaonga KKE, Mashingaidze K, Thokozile N, Mhike X, Prasanna BM. Tarekegne A, et al. Among authors: cairns je. Front Plant Sci. 2024 Jan 16;14:1321308. doi: 10.3389/fpls.2023.1321308. eCollection 2023. Front Plant Sci. 2024. PMID: 38293626 Free PMC article.
925 results