Cain RM - Search Results

1

Computational methods to identify new antibacterial targets.

McPhillie MJ, Cain RM, Narramore S, Fishwick CW, Simmons KJ. McPhillie MJ, et al. Among authors: cain rm. Chem Biol Drug Des. 2015 Jan;85(1):22-9. doi: 10.1111/cbdd.12385. Chem Biol Drug Des. 2015. PMID: 24974974

2

Applications of structure-based design to antibacterial drug discovery.

Cain R, Narramore S, McPhillie M, Simmons K, Fishwick CW. Cain R, et al. Bioorg Chem. 2014 Aug;55:69-76. doi: 10.1016/j.bioorg.2014.05.008. Epub 2014 Jun 2. Bioorg Chem. 2014. PMID: 24962384 Review.

3

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG. Cain R, et al. J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10. J Med Chem. 2018. PMID: 29271657 Free article.

4

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Calvopiña K, et al. Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21. Mol Microbiol. 2017. PMID: 28876489 Free article.

5

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J. Cahill ST, et al. Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7. Biochim Biophys Acta Gen Subj. 2019. PMID: 30738906 Free article.

6

Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.

Cain R, Salimraj R, Punekar AS, Bellini D, Fishwick CWG, Czaplewski L, Scott DJ, Harris G, Dowson CG, Lloyd AJ, Roper DI. Cain R, et al. J Med Chem. 2019 Nov 14;62(21):9703-9717. doi: 10.1021/acs.jmedchem.9b01131. Epub 2019 Nov 5. J Med Chem. 2019. PMID: 31626547 Free article.

7

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Brem J, et al. Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406. Nat Commun. 2016. PMID: 27499424 Free PMC article.

8

Cyclic Boronates Inhibit All Classes of β-Lactamases.

Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J. Cahill ST, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02260-16. doi: 10.1128/AAC.02260-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28115348 Free PMC article.

9

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli.

Lang PA, Parkova A, Leissing TM, Calvopiña K, Cain R, Krajnc A, Panduwawala TD, Philippe J, Fishwick CWG, Trapencieris P, Page MGP, Schofield CJ, Brem J. Lang PA, et al. Biomolecules. 2020 Jun 12;10(6):899. doi: 10.3390/biom10060899. Biomolecules. 2020. PMID: 32545682 Free PMC article.

10

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment.

Dilly SJ, Clark AJ, Marsh A, Mitchell DA, Cain R, Fishwick CWG, Taylor PC. Dilly SJ, et al. Cancer Lett. 2017 May 1;393:16-21. doi: 10.1016/j.canlet.2017.01.042. Epub 2017 Feb 8. Cancer Lett. 2017. PMID: 28188816 Free article.

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