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A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress.
Fedeles BI, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade DC, Westergerling P, Staudner T, Campolo J, Liu SS, Dong K, Cai Y, Rehman M, Gallagher AR, Ruchirawat S, Croy RG, Essigmann JM, Fedeles SV, Somlo S. Fedeles BI, et al. Among authors: cai y. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2317344121. doi: 10.1073/pnas.2317344121. Epub 2024 Jan 19. Proc Natl Acad Sci U S A. 2024. PMID: 38241440 Free PMC article.
Polycystin-2 is an intracellular calcium release channel.
Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S. Koulen P, et al. Among authors: cai y. Nat Cell Biol. 2002 Mar;4(3):191-7. doi: 10.1038/ncb754. Nat Cell Biol. 2002. PMID: 11854751
Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression.
Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, Somlo S, Caplan MJ. Bertuccio CA, et al. Among authors: cai y. J Biol Chem. 2009 Jul 31;284(31):21011-26. doi: 10.1074/jbc.M109.017756. Epub 2009 Jun 2. J Biol Chem. 2009. PMID: 19491093 Free PMC article.
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