Cai Y - Search Results

1

Molecular Basis for Drug Resistance in HIV-1 Protease.

Ali A, Bandaranayake RM, Cai Y, King NM, Kolli M, Mittal S, Murzycki JF, Nalam MNL, Nalivaika EA, Özen A, Prabu-Jeyabalan MM, Thayer K, Schiffer CA. Ali A, et al. Among authors: cai y. Viruses. 2010 Nov;2(11):2509-2535. doi: 10.3390/v2112509. Epub 2010 Nov 12. Viruses. 2010. PMID: 21994628 Free PMC article.

2

Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV.

Cai Y, Schiffer CA. Cai Y, et al. J Chem Theory Comput. 2010 Apr 13;6(4):1358-1368. doi: 10.1021/ct9004678. J Chem Theory Comput. 2010. PMID: 20543885 Free PMC article.

3

Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.

Cai Y, Schiffer C. Cai Y, et al. Methods Mol Biol. 2012;819:551-60. doi: 10.1007/978-1-61779-465-0_32. Methods Mol Biol. 2012. PMID: 22183557 Free PMC article.

4

Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.

Mittal S, Cai Y, Nalam MN, Bolon DN, Schiffer CA. Mittal S, et al. Among authors: cai y. J Am Chem Soc. 2012 Mar 7;134(9):4163-8. doi: 10.1021/ja2095766. Epub 2012 Feb 28. J Am Chem Soc. 2012. PMID: 22295904 Free PMC article.

5

Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.

Ragland DA, Nalivaika EA, Nalam MN, Prachanronarong KL, Cao H, Bandaranayake RM, Cai Y, Kurt-Yilmaz N, Schiffer CA. Ragland DA, et al. Among authors: cai y. J Am Chem Soc. 2014 Aug 27;136(34):11956-63. doi: 10.1021/ja504096m. Epub 2014 Aug 18. J Am Chem Soc. 2014. PMID: 25091085 Free PMC article.

6

Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation.

Cai Y, Yilmaz NK, Myint W, Ishima R, Schiffer CA. Cai Y, et al. J Chem Theory Comput. 2012 Oct 9;8(10):3452-3462. doi: 10.1021/ct300076y. Epub 2012 Apr 17. J Chem Theory Comput. 2012. PMID: 23144597 Free PMC article.

7

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease.

Cai Y, Myint W, Paulsen JL, Schiffer CA, Ishima R, Kurt Yilmaz N. Cai Y, et al. J Chem Theory Comput. 2014 Aug 12;10(8):3438-3448. doi: 10.1021/ct4010454. Epub 2014 Jun 12. J Chem Theory Comput. 2014. PMID: 25136270 Free PMC article.

Surprisingly this change in ensemble dynamics is different from that observed in the unliganded form of the same variant (Cai, Y. et al. J. Chem. Theory Comput.2012, 8, 3452-3462). Our comparative analysis of both inhibitor-free and bound states presents a comprehen …

Surprisingly this change in ensemble dynamics is different from that observed in the unliganded form of the same variant (Cai, Y …

8

Modulation of HIV protease flexibility by the T80N mutation.

Zhou H, Li S, Badger J, Nalivaika E, Cai Y, Foulkes-Murzycki J, Schiffer C, Makowski L. Zhou H, et al. Among authors: cai y. Proteins. 2015 Nov;83(11):1929-39. doi: 10.1002/prot.24737. Epub 2015 Sep 29. Proteins. 2015. PMID: 25488402 Free PMC article.

9

Quantitative comparison of errors in 15N transverse relaxation rates measured using various CPMG phasing schemes.

Myint W, Cai Y, Schiffer CA, Ishima R. Myint W, et al. Among authors: cai y. J Biomol NMR. 2012 May;53(1):13-23. doi: 10.1007/s10858-012-9621-x. Epub 2012 Apr 1. J Biomol NMR. 2012. PMID: 22466935 Free PMC article.

10

Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants.

Shen L, Yang Z, Gao C, Li L, Wang Y, Cai Y, Feng Z. Shen L, et al. Among authors: cai y. Pediatr Surg Int. 2024 May 2;40(1):115. doi: 10.1007/s00383-024-05697-x. Pediatr Surg Int. 2024. PMID: 38696138

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