Cai X - Search Results

1

Common activation mechanism of class A GPCRs.

Zhou Q, Yang D, Wu M, Guo Y, Guo W, Zhong L, Cai X, Dai A, Jang W, Shakhnovich EI, Liu ZJ, Stevens RC, Lambert NA, Babu MM, Wang MW, Zhao S. Zhou Q, et al. Among authors: cai x. Elife. 2019 Dec 19;8:e50279. doi: 10.7554/eLife.50279. Elife. 2019. PMID: 31855179 Free PMC article.

2

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).

Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW. Yang D, et al. Among authors: cai x. J Biol Chem. 2016 Jun 17;291(25):12991-3004. doi: 10.1074/jbc.M116.721977. Epub 2016 Apr 8. J Biol Chem. 2016. PMID: 27059958 Free PMC article.

3

Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists.

Shu S, Cai X, Li J, Feng Y, Dai A, Wang J, Yang D, Wang MW, Liu H. Shu S, et al. Among authors: cai x. Bioorg Med Chem. 2016 Jun 15;24(12):2852-63. doi: 10.1016/j.bmc.2016.04.053. Epub 2016 Apr 26. Bioorg Med Chem. 2016. PMID: 27161876

4

Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.

Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE. Zhao LH, et al. Among authors: cai x. J Biol Chem. 2016 Jul 15;291(29):15119-30. doi: 10.1074/jbc.M116.726620. Epub 2016 May 13. J Biol Chem. 2016. PMID: 27226600 Free PMC article.

5

Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors.

Yin Y, de Waal PW, He Y, Zhao LH, Yang D, Cai X, Jiang Y, Melcher K, Wang MW, Xu HE. Yin Y, et al. Among authors: cai x. J Biol Chem. 2017 Jun 16;292(24):9865-9881. doi: 10.1074/jbc.M117.782987. Epub 2017 Mar 29. J Biol Chem. 2017. PMID: 28356352 Free PMC article.

6

W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway.

Li T, Lin GY, Zhong L, Zhou Y, Wang J, Zhu Y, Feng Y, Cai XQ, Liu Q, Nosjean O, Boutin JA, Renard P, Yang DH, Wang MW. Li T, et al. Acta Pharmacol Sin. 2017 Jul;38(7):1024-1037. doi: 10.1038/aps.2017.15. Epub 2017 May 15. Acta Pharmacol Sin. 2017. PMID: 28502980 Free PMC article.

7

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC. Song G, et al. Among authors: cai x. Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17. Nature. 2017. PMID: 28514449

8

Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. Zhang H, et al. Among authors: cai x. Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17. Nature. 2017. PMID: 28514451 Free PMC article.

9

Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors.

Liu Q, Cai X, Yang D, Chen Y, Wang Y, Shao L, Wang MW. Liu Q, et al. Among authors: cai x. Bioorg Med Chem. 2017 Sep 1;25(17):4579-4594. doi: 10.1016/j.bmc.2017.06.032. Epub 2017 Jun 21. Bioorg Med Chem. 2017. PMID: 28739157

10

Structure of the glucagon receptor in complex with a glucagon analogue.

Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B. Zhang H, et al. Among authors: cai x. Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153. Nature. 2018. PMID: 29300013

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