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Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.
Zhang XJ, She ZG, Wang J, Sun D, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H. Zhang XJ, et al. Among authors: cai j. Sci Transl Med. 2021 Dec 15;13(624):eabg8117. doi: 10.1126/scitranslmed.abg8117. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910546
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. Zhang XJ, et al. Among authors: cai j. Sci Transl Med. 2021 Dec 15;13(624):eabg8116. doi: 10.1126/scitranslmed.abg8116. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910548
The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
Liu J, Li W, Deng KQ, Tian S, Liu H, Shi H, Fang Q, Liu Z, Chen Z, Tian T, Gan S, Hu F, Hu M, Cheng X, Ji YX, Zhang P, She ZG, Zhang XJ, Chen S, Cai J, Li H. Liu J, et al. Among authors: cai j. Circ Res. 2022 May 13;130(10):1586-1600. doi: 10.1161/CIRCRESAHA.121.318866. Epub 2022 Apr 19. Circ Res. 2022. PMID: 35437018 Free article.
Recent updates on targeting the molecular mediators of NAFLD.
Wang J, Wang L, Zhang XJ, Zhang P, Cai J, She ZG, Li H. Wang J, et al. Among authors: cai j. J Mol Med (Berl). 2023 Feb;101(1-2):101-124. doi: 10.1007/s00109-022-02282-4. Epub 2023 Feb 16. J Mol Med (Berl). 2023. PMID: 36792729 Review.
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