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Small-molecule agents for treating skin diseases.
Cai H, Wen H, Li J, Lu L, Zhao W, Jiang X, Bai R. Cai H, et al. Eur J Med Chem. 2024 Mar 15;268:116269. doi: 10.1016/j.ejmech.2024.116269. Epub 2024 Feb 24. Eur J Med Chem. 2024. PMID: 38422702 Review.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Jurica EA, Wu X, Williams KN, Haque LE, Rampulla RA, Mathur A, Zhou M, Cao G, Cai H, Wang T, Liu H, Xu C, Kunselman LK, Antrilli TM, Hicks MB, Sun Q, Dierks EA, Apedo A, Moore DB, Foster KA, Cvijic ME, Panemangalore R, Khandelwal P, Wilkes JJ, Zinker BA, Robertson DG, Janovitz EB, Galella M, Li YX, Li J, Ramar T, Jalagam PR, Jayaram R, Whaley JM, Barrish JC, Robl JA, Ewing WR, Ellsworth BA. Jurica EA, et al. Among authors: cai h. Bioorg Med Chem. 2023 May 1;85:117273. doi: 10.1016/j.bmc.2023.117273. Epub 2023 Apr 4. Bioorg Med Chem. 2023. PMID: 37030194
Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).
Chiu G, Li S, Cai H, Connolly PJ, Peng S, Stauber K, Pulito V, Liu J, Middleton SA. Chiu G, et al. Among authors: cai h. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6123-8. doi: 10.1016/j.bmcl.2007.09.051. Epub 2007 Sep 18. Bioorg Med Chem Lett. 2007. PMID: 17904840
8,221 results