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Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach.
Soto R, Perez-Herran E, Rodriguez B, Duma BM, Cacho-Izquierdo M, Mendoza-Losana A, Lelievre J, Aguirre DB, Ballell L, Cox LR, Alderwick LJ, Besra GS. Soto R, et al. Among authors: cacho izquierdo m. Sci Rep. 2018 Aug 23;8(1):12664. doi: 10.1038/s41598-018-31157-3. Sci Rep. 2018. PMID: 30140040 Free PMC article.
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.
Batt SM, Cacho Izquierdo M, Castro Pichel J, Stubbs CJ, Vela-Glez Del Peral L, Pérez-Herrán E, Dhar N, Mouzon B, Rees M, Hutchinson JP, Young RJ, McKinney JD, Barros Aguirre D, Ballell L, Besra GS, Argyrou A. Batt SM, et al. Among authors: cacho izquierdo m. ACS Infect Dis. 2015 Dec 11;1(12):615-26. doi: 10.1021/acsinfecdis.5b00065. Epub 2015 Aug 25. ACS Infect Dis. 2015. PMID: 27623058
A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus.
Ganapathy US, Del Río RG, Cacho-Izquierdo M, Ortega F, Lelièvre J, Barros-Aguirre D, Aragaw WW, Zimmerman MD, Lindman M, Dartois V, Gengenbacher M, Dick T. Ganapathy US, et al. Among authors: cacho izquierdo m. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0151421. doi: 10.1128/AAC.01514-21. Epub 2021 Oct 4. Antimicrob Agents Chemother. 2021. PMID: 34606340 Free PMC article.
A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity.
Ganapathy US, Del Rio RG, Cacho-Izquierdo M, Ortega F, Lelièvre J, Barros-Aguirre D, Lindman M, Dartois V, Gengenbacher M, Dick T. Ganapathy US, et al. Among authors: cacho izquierdo m. Antimicrob Agents Chemother. 2023 May 1;95(5):e02420-20. doi: 10.1128/AAC.02420-20. Epub 2021 Feb 8. Antimicrob Agents Chemother. 2023. PMID: 33558292 Free PMC article.
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.
Negatu DA, González Del Río R, Cacho-Izquierdo M, Barros-Aguirre D, Lelievre J, Rullas J, Casado P, Ganapathy US, Zimmerman MD, Gengenbacher M, Dartois V, Dick T. Negatu DA, et al. Among authors: cacho izquierdo m. Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0145922. doi: 10.1128/aac.01459-22. Epub 2023 Jan 23. Antimicrob Agents Chemother. 2023. PMID: 36688684 Free PMC article.