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Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia.
Fisher-Wellman KH, Kassai M, Hagen JT, Neufer PD, Kester M, Loughran TP Jr, Chalfant CE, Feith DJ, Tan SF, Fox TE, Ung J, Fabrias G, Abad JL, Sharma A, Golla U, Claxton DF, Shaw JJP, Bhowmick D, Cabot MC. Fisher-Wellman KH, et al. Among authors: cabot mc. Cancers (Basel). 2023 Mar 21;15(6):1883. doi: 10.3390/cancers15061883. Cancers (Basel). 2023. PMID: 36980769 Free PMC article.
Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes.
Paudel BB, Tan SF, Fox TE, Ung J, Shaw J, Dunton W, Lee I, Sharma A, Viny AD, Barth BM, Tallman MS, Cabot M, Garrett-Bakelman FE, Levine RL, Kester M, Claxton D, Feith DJ, Janes KA, Loughran TP Jr. Paudel BB, et al. bioRxiv [Preprint]. 2023 Apr 17:2023.04.13.536805. doi: 10.1101/2023.04.13.536805. bioRxiv. 2023. PMID: 37131653 Free PMC article. Updated. Preprint.
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.
Ung J, Tan SF, Fox TE, Shaw JJ, Taori M, Horton BJ, Golla U, Sharma A, Szulc ZM, Wang HG, Chalfant CE, Cabot MC, Claxton DF, Loughran TP, Feith DJ. Ung J, et al. Among authors: cabot mc. bioRxiv [Preprint]. 2023 Oct 23:2023.10.21.563437. doi: 10.1101/2023.10.21.563437. bioRxiv. 2023. PMID: 37961314 Free PMC article. Updated. Preprint.
Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes.
Paudel BB, Tan SF, Fox TE, Ung J, Golla U, Shaw JJP, Dunton W, Lee I, Fares WA, Patel S, Sharma A, Viny AD, Barth BM, Tallman MS, Cabot M, Garrett-Bakelman FE, Levine RL, Kester M, Feith DJ, Claxton D, Janes KA, Loughran TP Jr. Paudel BB, et al. Blood Adv. 2024 Mar 12;8(5):1137-1142. doi: 10.1182/bloodadvances.2023010535. Blood Adv. 2024. PMID: 38170742 Free PMC article. No abstract available.
Mitochondria inside acute myeloid leukemia cells hydrolyze ATP to resist chemotherapy.
Hagen JT, Montgomery MM, Aruleba RT, Chrest BR, Green TD, Kassai M, Zeczycki TN, Schmidt CA, Bhowmick D, Tan SF, Feith DJ, Chalfant CE, Loughran TP Jr, Liles D, Minden MD, Schimmer AD, Cabot MC, Mclung JM, Fisher-Wellman KH. Hagen JT, et al. Among authors: cabot mc. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589110. doi: 10.1101/2024.04.12.589110. bioRxiv. 2024. PMID: 38659944 Free PMC article. Preprint.
Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells.
Hagen JT, Montgomery MM, Biagioni EM, Krassovskaia P, Jevtovic F, Shookster D, Sharma U, Tung K, Broskey NT, May L, Huang H, Brault JJ, Neufer PD, Cabot MC, Fisher-Wellman KH. Hagen JT, et al. Among authors: cabot mc. Biochim Biophys Acta Bioenerg. 2022 Nov 1;1863(8):148915. doi: 10.1016/j.bbabio.2022.148915. Epub 2022 Sep 2. Biochim Biophys Acta Bioenerg. 2022. PMID: 36058252 Free PMC article.
Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia.
Ung J, Tan SF, Fox TE, Shaw JJP, Vass LR, Costa-Pinheiro P, Garrett-Bakelman FE, Keng MK, Sharma A, Claxton DF, Levine RL, Tallman MS, Cabot MC, Kester M, Feith DJ, Loughran TP Jr. Ung J, et al. Among authors: cabot mc. Blood Rev. 2022 Sep;55:100950. doi: 10.1016/j.blre.2022.100950. Epub 2022 Apr 9. Blood Rev. 2022. PMID: 35487785 Free PMC article. Review.
125 results