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AAV-p40 Bioengineering Platform for Variant Selection Based on Transgene Expression.
Westhaus A, Cabanes-Creus M, Jonker T, Sallard E, Navarro RG, Zhu E, Baltazar Torres G, Lee S, Wilmott P, Gonzalez-Cordero A, Santilli G, Thrasher AJ, Alexander IE, Lisowski L. Westhaus A, et al. Among authors: cabanes creus m. Hum Gene Ther. 2022 Jun;33(11-12):664-682. doi: 10.1089/hum.2021.278. Epub 2022 May 6. Hum Gene Ther. 2022. PMID: 35297686 Free PMC article.
Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality.
Cabanes-Creus M, Ginn SL, Amaya AK, Liao SHY, Westhaus A, Hallwirth CV, Wilmott P, Ward J, Dilworth KL, Santilli G, Rybicki A, Nakai H, Thrasher AJ, Filip AC, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Mol Ther Methods Clin Dev. 2018 Nov 1;12:71-84. doi: 10.1016/j.omtm.2018.10.016. eCollection 2019 Mar 15. Mol Ther Methods Clin Dev. 2018. PMID: 30534580 Free PMC article.
High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction.
Westhaus A, Cabanes-Creus M, Rybicki A, Baltazar G, Navarro RG, Zhu E, Drouyer M, Knight M, Albu RF, Ng BH, Kalajdzic P, Kwiatek M, Hsu K, Santilli G, Gold W, Kramer B, Gonzalez-Cordero A, Thrasher AJ, Alexander IE, Lisowski L. Westhaus A, et al. Hum Gene Ther. 2020 May;31(9-10):575-589. doi: 10.1089/hum.2019.264. Epub 2020 Feb 26. Hum Gene Ther. 2020. PMID: 32000541 Free PMC article.
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2.
Cabanes-Creus M, Westhaus A, Navarro RG, Baltazar G, Zhu E, Amaya AK, Liao SHY, Scott S, Sallard E, Dilworth KL, Rybicki A, Drouyer M, Hallwirth CV, Bennett A, Santilli G, Thrasher AJ, Agbandje-McKenna M, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Mol Ther Methods Clin Dev. 2020 May 13;17:1139-1154. doi: 10.1016/j.omtm.2020.05.004. eCollection 2020 Jun 12. Mol Ther Methods Clin Dev. 2020. PMID: 32490035 Free PMC article.
Restoring the natural tropism of AAV2 vectors for human liver.
Cabanes-Creus M, Hallwirth CV, Westhaus A, Ng BH, Liao SHY, Zhu E, Navarro RG, Baltazar G, Drouyer M, Scott S, Logan GJ, Santilli G, Bennett A, Ginn SL, McCaughan G, Thrasher AJ, Agbandje-McKenna M, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Sci Transl Med. 2020 Sep 9;12(560):eaba3312. doi: 10.1126/scitranslmed.aba3312. Sci Transl Med. 2020. PMID: 32908003
Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8.
Cabanes-Creus M, Navarro RG, Zhu E, Baltazar G, Liao SHY, Drouyer M, Amaya AK, Scott S, Nguyen LH, Westhaus A, Hebben M, Wilson LOW, Thrasher AJ, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Mol Ther Methods Clin Dev. 2021 Nov 25;24:88-101. doi: 10.1016/j.omtm.2021.11.011. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2021. PMID: 34977275 Free PMC article.
Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy.
Meumann N, Cabanes-Creus M, Ertelt M, Navarro RG, Lucifora J, Yuan Q, Nien-Huber K, Abdelrahman A, Vu XK, Zhang L, Franke AC, Schmithals C, Piiper A, Vogt A, Gonzalez-Carmona M, Frueh JT, Ullrich E, Meuleman P, Talbot SR, Odenthal M, Ott M, Seifried E, Schoeder CT, Schwäble J, Lisowski L, Büning H. Meumann N, et al. Among authors: cabanes creus m. Hepatology. 2023 Mar 1;77(3):802-815. doi: 10.1002/hep.32733. Epub 2023 Feb 17. Hepatology. 2023. PMID: 35976053 Free PMC article.
Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution.
Cabanes-Creus M, Navarro RG, Liao SHY, Scott S, Carlessi R, Roca-Pinilla R, Knight M, Baltazar G, Zhu E, Jones M, Denisenko E, Forrest ARR, Alexander IE, Tirnitz-Parker JEE, Lisowski L. Cabanes-Creus M, et al. Mol Ther Methods Clin Dev. 2023 Jan 2;28:220-237. doi: 10.1016/j.omtm.2022.12.014. eCollection 2023 Mar 9. Mol Ther Methods Clin Dev. 2023. PMID: 36700121 Free PMC article.
16 results