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iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System.
Hastedt JE, Bäckman P, Cabal A, Clark A, Ehrhardt C, Forbes B, Hickey AJ, Hochhaus G, Jiang W, Kassinos S, Kuehl PJ, Prime D, Son YJ, Teague S, Tehler U, Wylie J. Hastedt JE, et al. Among authors: cabal a. Mol Pharm. 2022 Jul 4;19(7):2032-2039. doi: 10.1021/acs.molpharmaceut.2c00113. Epub 2022 May 16. Mol Pharm. 2022. PMID: 35576168 Free PMC article. Review.
iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes.
Bäckman P, Cabal A, Clark A, Ehrhardt C, Forbes B, Hastedt J, Hickey A, Hochhaus G, Jiang W, Kassinos S, Kuehl PJ, Prime D, Son YJ, Teague SP, Tehler U, Wylie J. Bäckman P, et al. Among authors: cabal a. Mol Pharm. 2022 Jul 4;19(7):2040-2047. doi: 10.1021/acs.molpharmaceut.2c00112. Epub 2022 May 24. Mol Pharm. 2022. PMID: 35609877 Free PMC article.
Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions.
Caniga M, Cabal A, Mehta K, Ross DS, Gil MA, Woodhouse JD, Eckman J, Naber JR, Callahan MK, Goncalves L, Hill SE, Mcleod RL, McIntosh F, Freke MC, Visser SA, Johnson N, Salmon M, Cicmil M. Caniga M, et al. Among authors: cabal a. J Aerosol Med Pulm Drug Deliv. 2016 Aug;29(4):362-77. doi: 10.1089/jamp.2015.1253. Epub 2016 Feb 9. J Aerosol Med Pulm Drug Deliv. 2016. PMID: 26859446
Mathematical Model of Bone Remodeling Captures the Antiresorptive and Anabolic Actions of Various Therapies.
Ross DS, Mehta K, Cabal A. Ross DS, et al. Among authors: cabal a. Bull Math Biol. 2017 Jan;79(1):117-142. doi: 10.1007/s11538-016-0229-2. Epub 2016 Nov 30. Bull Math Biol. 2017. PMID: 27905067
We have also incorporated a basic model of the effects of vitamin D on calcium homeostasis. ...Finally, we have devised a simple model of the administration and effects of bisphosphonates. ...
We have also incorporated a basic model of the effects of vitamin D on calcium homeostasis. ...Finally, we have devised a simp …
Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation.
McLeod RL, Gil MA, Chen D, Cabal A, Katz J, Methot J, Woodhouse JD, Dorosh L, Geda P, Mehta K, Cicmil M, Baltus GA, Bass A, Houshyar H, Caniga M, Yu H, Gervais F, Alves S, Shah S. McLeod RL, et al. Among authors: cabal a. J Pharmacol Exp Ther. 2019 May;369(2):223-233. doi: 10.1124/jpet.118.252551. Epub 2019 Feb 25. J Pharmacol Exp Ther. 2019. PMID: 30804001
Current practices for QSP model assessment: an IQ consortium survey.
Chan JR, Allen R, Boras B, Cabal A, Damian V, Gibbons FD, Gulati A, Hosseini I, Kearns JD, Saito R, Cucurull-Sanchez L, Selimkhanov J, Stein AM, Umehara K, Wang G, Wang W, Neves-Zaph S. Chan JR, et al. Among authors: cabal a. J Pharmacokinet Pharmacodyn. 2022 Aug 11:1-13. doi: 10.1007/s10928-022-09811-1. Online ahead of print. J Pharmacokinet Pharmacodyn. 2022. PMID: 35953664 Free PMC article.
Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: a study with odanacatib treatment in the ovariectomized adult rhesus monkey.
Jayakar RY, Cabal A, Szumiloski J, Sardesai S, Phillips EA, Laib A, Scott BB, Pickarski M, Duong LT, Winkelmann CT, McCracken PJ, Hargreaves R, Hangartner TN, Williams DS. Jayakar RY, et al. Among authors: cabal a. Bone. 2012 Jun;50(6):1379-88. doi: 10.1016/j.bone.2012.03.017. Epub 2012 Mar 24. Bone. 2012. PMID: 22469953
High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate.
Cabal A, Jayakar RY, Sardesai S, Phillips EA, Szumiloski J, Posavec DJ, Mathers PD, Savitz AT, Scott BB, Winkelmann CT, Motzel S, Cook L, Hargreaves R, Evelhoch JL, Dardzinski BJ, Hangartner TN, McCracken PJ, Duong LT, Williams DS. Cabal A, et al. Bone. 2013 Oct;56(2):497-505. doi: 10.1016/j.bone.2013.06.011. Epub 2013 Jun 20. Bone. 2013. PMID: 23791777
Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate.
Williams DS, McCracken PJ, Purcell M, Pickarski M, Mathers PD, Savitz AT, Szumiloski J, Jayakar RY, Somayajula S, Krause S, Brown K, Winkelmann CT, Scott BB, Cook L, Motzel SL, Hargreaves R, Evelhoch JL, Cabal A, Dardzinski BJ, Hangartner TN, Duong LT. Williams DS, et al. Among authors: cabal a. Bone. 2013 Oct;56(2):489-96. doi: 10.1016/j.bone.2013.06.008. Epub 2013 Jun 24. Bone. 2013. PMID: 23806798
72 results