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LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.
Liu F, Xu W, Wang Y, Huang Z, Zhu Z, Ou W, Tang W, Fu J, Liu C, Gu Y, Liu Y, Du P. Liu F, et al. Inflamm Bowel Dis. 2024 Feb 1;30(2):257-272. doi: 10.1093/ibd/izad140. Inflamm Bowel Dis. 2024. PMID: 37454278
RESULTS: LAMB3 expression was increased in inflammatory states in intestinal epithelial cells and colonoids and was associated with adverse clinical outcomes in Crohn's disease. Knockdown of LAMB3 inhibited the expression of proinflammatory cytokines. ...CONCLUSION: …
RESULTS: LAMB3 expression was increased in inflammatory states in intestinal epithelial cells and colonoids and was associated with adverse …
Single-Cell Sequencing-Based Validation of T Cell-Associated Diagnostic Model Genes and Drug Response in Crohn's Disease.
Dai Z, Zhang J, Xu W, Du P, Wang Z, Liu Y. Dai Z, et al. Int J Mol Sci. 2023 Mar 23;24(7):6054. doi: 10.3390/ijms24076054. Int J Mol Sci. 2023. PMID: 37047025 Free PMC article.
Crohn's disease is a highly heterogeneous autoimmune disease with a unique inflammatory phenotype of T cells at the lesion site. We aim to further explore the diagnosis of Crohn's disease and drug prediction of T cell marker gene expression. ...
Crohn's disease is a highly heterogeneous autoimmune disease with a unique inflammatory phenotype of T cells at the lesion sit …