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Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.
Nat Commun. 2023 Dec 11;14(1):7830. doi: 10.1038/s41467-023-43475-w.
Nat Commun. 2023.
PMID: 38081835
Free PMC article.
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir SK, Axtman AD.
Castano A, et al.
Elife. 2023 Jul 25;12:e88206. doi: 10.7554/eLife.88206.
Elife. 2023.
PMID: 37490324
Free PMC article.
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