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Chiral Cyclobutane-Containing Cell-Penetrating Peptides as Selective Vectors for Anti-Leishmania Drug Delivery Systems.
Illa O, Olivares JA, Gaztelumendi N, Martínez-Castro L, Ospina J, Abengozar MÁ, Sciortino G, Maréchal JD, Nogués C, Royo M, Rivas L, Ortuño RM. Illa O, et al. Int J Mol Sci. 2020 Oct 12;21(20):7502. doi: 10.3390/ijms21207502. Int J Mol Sci. 2020. PMID: 33053805 Free PMC article.
They were conjugated to fluorescent doxorubicin (Dox) as a standard drug showing toxicity beyond 1 muM, while free Dox was not toxic. ...The conformational structure of the conjugates was approached both by circular dichroism spectroscopy and molecular dynamics simulations …
They were conjugated to fluorescent doxorubicin (Dox) as a standard drug showing toxicity beyond 1 muM, while free Dox was not toxic. …