CA140474/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2011	3
2012	1
2013	4
2014	3
2015	3
2016	1
2017	3
2018	1
2024	0

1

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping.

Wu G, Fan L, Edmonson MN, Shaw T, Boggs K, Easton J, Rusch MC, Webb TR, Zhang J, Potter PM. Wu G, et al. RNA. 2018 Aug;24(8):1056-1066. doi: 10.1261/rna.065383.117. Epub 2018 May 29. RNA. 2018. PMID: 29844105 Free PMC article.

2

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

Fraile JM, Manchado E, Lujambio A, Quesada V, Campos-Iglesias D, Webb TR, Lowe SW, López-Otín C, Freije JM. Fraile JM, et al. J Biol Chem. 2017 Mar 10;292(10):4164-4175. doi: 10.1074/jbc.M116.762757. Epub 2017 Feb 1. J Biol Chem. 2017. PMID: 28154181 Free PMC article.

3

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.

Shirai CL, White BS, Tripathi M, Tapia R, Ley JN, Ndonwi M, Kim S, Shao J, Carver A, Saez B, Fulton RS, Fronick C, O'Laughlin M, Lagisetti C, Webb TR, Graubert TA, Walter MJ. Shirai CL, et al. Nat Commun. 2017 Jan 9;8:14060. doi: 10.1038/ncomms14060. Nat Commun. 2017. PMID: 28067246 Free PMC article.

4

A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.

Shi Y, Park J, Lagisetti C, Zhou W, Sambucetti LC, Webb TR. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412. doi: 10.1016/j.bmcl.2016.12.056. Epub 2016 Dec 24. Bioorg Med Chem Lett. 2017. PMID: 28049589 Free PMC article.

5

The spliceosome is a therapeutic vulnerability in MYC-driven cancer.

Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. Hsu TY, et al. Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2. Nature. 2015. PMID: 26331541 Free PMC article.

6

Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates.

Shi Y, Joyner AS, Shadrick W, Palacios G, Lagisetti C, Potter PM, Sambucetti LC, Stamm S, Webb TR. Shi Y, et al. Pharmacol Res Perspect. 2015 Aug;3(4):e00158. doi: 10.1002/prp2.158. Epub 2015 Jun 26. Pharmacol Res Perspect. 2015. PMID: 26171237 Free PMC article.

7

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.

Xargay-Torrent S, López-Guerra M, Rosich L, Montraveta A, Roldán J, Rodríguez V, Villamor N, Aymerich M, Lagisetti C, Webb TR, López-Otín C, Campo E, Colomer D. Xargay-Torrent S, et al. Oncotarget. 2015 Sep 8;6(26):22734-49. doi: 10.18632/oncotarget.4212. Oncotarget. 2015. PMID: 26068951 Free PMC article.

8

HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia.

Thénoz M, Vernin C, Mortada H, Karam M, Pinatel C, Gessain A, Webb TR, Auboeuf D, Wattel E, Mortreux F. Thénoz M, et al. Retrovirology. 2014 Dec 18;11:119. doi: 10.1186/s12977-014-0119-3. Retrovirology. 2014. PMID: 25519886 Free PMC article.

9

Sudemycin E influences alternative splicing and changes chromatin modifications.

Convertini P, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S. Convertini P, et al. Nucleic Acids Res. 2014 Apr;42(8):4947-61. doi: 10.1093/nar/gku151. Epub 2014 Mar 11. Nucleic Acids Res. 2014. PMID: 24623796 Free PMC article.

10

Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.

Lagisetti C, Yermolina MV, Sharma LK, Palacios G, Prigaro BJ, Webb TR. Lagisetti C, et al. ACS Chem Biol. 2014 Mar 21;9(3):643-8. doi: 10.1021/cb400695j. Epub 2013 Dec 30. ACS Chem Biol. 2014. PMID: 24377313 Free PMC article.

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