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Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry.
Carvajal-Hausdorf DE, Patsenker J, Stanton KP, Villarroel-Espindola F, Esch A, Montgomery RR, Psyrri A, Kalogeras KT, Kotoula V, Foutzilas G, Schalper KA, Kluger Y, Rimm DL. Carvajal-Hausdorf DE, et al. Clin Cancer Res. 2019 May 15;25(10):3054-3062. doi: 10.1158/1078-0432.CCR-18-2599. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796036 Free PMC article. Clinical Trial.
High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence.
Wasserman BE, Carvajal-Hausdorf DE, Ho K, Wong W, Wu N, Chu VC, Lai EW, Weidler JM, Bates M, Neumeister V, Rimm DL. Wasserman BE, et al. Lab Invest. 2017 Dec;97(12):1521-1526. doi: 10.1038/labinvest.2017.93. Epub 2017 Sep 11. Lab Invest. 2017. PMID: 28892092 Free PMC article.
Unvalidated antibodies and misleading results.
Rimm D, Schalper K, Pusztai L. Rimm D, et al. Breast Cancer Res Treat. 2014 Sep;147(2):457-8. doi: 10.1007/s10549-014-3061-0. Epub 2014 Aug 3. Breast Cancer Res Treat. 2014. PMID: 25086631 Free PMC article. No abstract available.
Antibody validation.
Bordeaux J, Welsh A, Agarwal S, Killiam E, Baquero M, Hanna J, Anagnostou V, Rimm D. Bordeaux J, et al. Biotechniques. 2010 Mar;48(3):197-209. doi: 10.2144/000113382. Biotechniques. 2010. PMID: 20359301 Free PMC article. Review.