CA111803/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2007	1
2008	1
2009	5
2011	3
2012	4
2014	1
2024	0

1

Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor.

Yu Z, Cai C, Gao S, Simon NI, Shen HC, Balk SP. Yu Z, et al. Clin Cancer Res. 2014 Aug 1;20(15):4075-85. doi: 10.1158/1078-0432.CCR-14-0292. Epub 2014 May 29. Clin Cancer Res. 2014. PMID: 24874833 Free PMC article.

2

EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.

Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, Xu H, Cato L, Thornton JE, Gregory RI, Morrissey C, Vessella RL, Montironi R, Magi-Galluzzi C, Kantoff PW, Balk SP, Liu XS, Brown M. Xu K, et al. Science. 2012 Dec 14;338(6113):1465-9. doi: 10.1126/science.1227604. Science. 2012. PMID: 23239736 Free PMC article.

3

In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer.

Shen HC, Shanmugasundaram K, Simon NI, Cai C, Wang H, Chen S, Balk SP, Rigby AC. Shen HC, et al. Mol Endocrinol. 2012 Nov;26(11):1836-46. doi: 10.1210/me.2012-1222. Epub 2012 Sep 28. Mol Endocrinol. 2012. PMID: 23023563 Free PMC article.

4

Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation.

Wang H, Xu Y, Fang Z, Chen S, Balk SP, Yuan X. Wang H, et al. PLoS One. 2012;7(7):e41330. doi: 10.1371/journal.pone.0041330. Epub 2012 Jul 23. PLoS One. 2012. PMID: 22844460 Free PMC article.

5

Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation.

Chen S, Gulla S, Cai C, Balk SP. Chen S, et al. J Biol Chem. 2012 Mar 9;287(11):8571-83. doi: 10.1074/jbc.M111.325290. Epub 2012 Jan 24. J Biol Chem. 2012. PMID: 22275373 Free PMC article.

6

Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.

Cai C, He HH, Chen S, Coleman I, Wang H, Fang Z, Chen S, Nelson PS, Liu XS, Brown M, Balk SP. Cai C, et al. Cancer Cell. 2011 Oct 18;20(4):457-71. doi: 10.1016/j.ccr.2011.09.001. Cancer Cell. 2011. PMID: 22014572 Free PMC article.

7

Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.

Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, Marck B, Matsumoto AM, Simon NI, Wang H, Chen S, Balk SP. Cai C, et al. Cancer Res. 2011 Oct 15;71(20):6503-13. doi: 10.1158/0008-5472.CAN-11-0532. Epub 2011 Aug 25. Cancer Res. 2011. PMID: 21868758 Free PMC article.

8

Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy.

Cai C, Balk SP. Cai C, et al. Endocr Relat Cancer. 2011 Aug 30;18(5):R175-82. doi: 10.1530/ERC-10-0339. Print 2011 Oct. Endocr Relat Cancer. 2011. PMID: 21712345 Free PMC article. Review.

9

Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer.

Taplin ME, Regan MM, Ko YJ, Bubley GJ, Duggan SE, Werner L, Beer TM, Ryan CW, Mathew P, Tu SM, Denmeade SR, Oh WK, Sartor O, Mantzoros CS, Rittmaster R, Kantoff PW, Balk SP. Taplin ME, et al. Clin Cancer Res. 2009 Nov 15;15(22):7099-105. doi: 10.1158/1078-0432.CCR-09-1722. Epub 2009 Nov 3. Clin Cancer Res. 2009. PMID: 19887483 Free PMC article. Clinical Trial.

10

Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1.

Chen S, Kesler CT, Paschal BM, Balk SP. Chen S, et al. J Biol Chem. 2009 Sep 18;284(38):25576-84. doi: 10.1074/jbc.M109.043133. Epub 2009 Jul 21. J Biol Chem. 2009. PMID: 19622840 Free PMC article.

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