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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Olive KP, et al. Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21. Science. 2009. PMID: 19460966 Free PMC article.
Modelling oncogenic Ras/Raf signalling in the mouse.
Karreth FA, Tuveson DA. Karreth FA, et al. Curr Opin Genet Dev. 2009 Feb;19(1):4-11. doi: 10.1016/j.gde.2008.12.006. Epub 2009 Feb 7. Curr Opin Genet Dev. 2009. PMID: 19201597 Free PMC article. Review.
Maximizing mouse cancer models.
Frese KK, Tuveson DA. Frese KK, et al. Nat Rev Cancer. 2007 Sep;7(9):645-58. doi: 10.1038/nrc2192. Nat Rev Cancer. 2007. PMID: 17687385 Review.