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Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, Zhang FX, Weng XQ, Shen ZX, Chen J, Gu LJ, Yan M, Zhang DE, Chen SJ, Wang ZY, Chen Z. Zhou GB, et al. Blood. 2007 Apr 15;109(8):3441-50. doi: 10.1182/blood-2006-06-032250. Epub 2006 Dec 29. Blood. 2007. PMID: 17197433 Free PMC article.