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ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B, Serrels A, Parsons M, Squire A, Birdsey GM, Randi AM, Bolado-Carrancio A, Gangeswaran R, Reynolds LE, Bodrug N, Wang Y, Wang J, Meier P, Hodivala-Dilke KM. D'Amico G, et al. Development. 2022 Jul 1;149(13):dev200528. doi: 10.1242/dev.200528. Epub 2022 Jul 12. Development. 2022. PMID: 35723257 Free PMC article.
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Gangoso E, Southgate B, Bradley L, Rus S, Galvez-Cancino F, McGivern N, Güç E, Kapourani CA, Byron A, Ferguson KM, Alfazema N, Morrison G, Grant V, Blin C, Sou I, Marques-Torrejon MA, Conde L, Parrinello S, Herrero J, Beck S, Brandner S, Brennan PM, Bertone P, Pollard JW, Quezada SA, Sproul D, Frame MC, Serrels A, Pollard SM. Gangoso E, et al. Cell. 2021 Apr 29;184(9):2454-2470.e26. doi: 10.1016/j.cell.2021.03.023. Epub 2021 Apr 14. Cell. 2021. PMID: 33857425 Free PMC article.
Targeting FAK in anticancer combination therapies.
Dawson JC, Serrels A, Stupack DG, Schlaepfer DD, Frame MC. Dawson JC, et al. Nat Rev Cancer. 2021 May;21(5):313-324. doi: 10.1038/s41568-021-00340-6. Epub 2021 Mar 17. Nat Rev Cancer. 2021. PMID: 33731845 Free PMC article. Review.