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Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling.
Deroche L, Aranzana-Climent V, Rozenholc A, Prouvensier L, Darnaud L, Grégoire N, Marchand S, Ploy M-C, François B, Couet W, Barraud O, Buyck JM. Deroche L, et al. Among authors: buyck jm. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0048023. doi: 10.1128/aac.00480-23. Epub 2023 Sep 11. Antimicrob Agents Chemother. 2023. PMID: 37695298 Free PMC article.
Sequential Time-Kill, a Simple Experimental Trick To Discriminate between Pharmacokinetics/Pharmacodynamics Models with Distinct Heterogeneous Subpopulations versus Homogenous Population with Adaptive Resistance.
Chauzy A, Ih H, Jacobs M, Marchand S, Grégoire N, Couet W, Buyck JM. Chauzy A, et al. Among authors: buyck jm. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00788-20. doi: 10.1128/AAC.00788-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32513802 Free PMC article.
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates.
Aubry R, Buyck J, Prouvensier L, Decousser J-W, Nordmann P, Wicha SG, Marchand S, Grégoire N. Aubry R, et al. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0030123. doi: 10.1128/aac.00301-23. Epub 2023 Sep 8. Antimicrob Agents Chemother. 2023. PMID: 37681977 Free PMC article.
Semimechanistic Pharmacodynamic Modeling of Aztreonam-Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug-Resistant Gram-Negative Bacteria.
Chauzy A, Gaelzer Silva Torres B, Buyck J, de Jonge B, Adier C, Marchand S, Couet W, Grégoire N. Chauzy A, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):815-824. doi: 10.1002/psp4.12452. Epub 2019 Aug 16. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31420947 Free PMC article.
33 results