Butters TD - Search Results

1

Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors.

Ayers BJ, Glawar AF, Martínez RF, Ngo N, Liu Z, Fleet GW, Butters TD, Nash RJ, Yu CY, Wormald MR, Nakagawa S, Adachi I, Kato A, Jenkinson SF. Ayers BJ, et al. Among authors: butters td. J Org Chem. 2014 Apr 18;79(8):3398-409. doi: 10.1021/jo500157p. Epub 2014 Apr 7. J Org Chem. 2014. PMID: 24641544

2

Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol.

Araújo N, Jenkinson SF, Martínez RF, Glawar AF, Wormald MR, Butters TD, Nakagawa S, Adachi I, Kato A, Yoshihara A, Akimitsu K, Izumori K, Fleet GW. Araújo N, et al. Among authors: butters td. Org Lett. 2012 Aug 17;14(16):4174-7. doi: 10.1021/ol301844n. Epub 2012 Jul 27. Org Lett. 2012. PMID: 22839435

3

3-Hydroxyazetidine carboxylic acids: non-proteinogenic amino acids for medicinal chemists.

Glawar AF, Jenkinson SF, Thompson AL, Nakagawa S, Kato A, Butters TD, Fleet GW. Glawar AF, et al. Among authors: butters td. ChemMedChem. 2013 Apr;8(4):658-66. doi: 10.1002/cmdc.201200541. Epub 2013 Mar 6. ChemMedChem. 2013. PMID: 23468173

4

C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.

Jenkinson SF, Best D, Saville AW, Mui J, Martínez RF, Nakagawa S, Kunimatsu T, Alonzi DS, Butters TD, Norez C, Becq F, Blériot Y, Wilson FX, Weymouth-Wilson AC, Kato A, Fleet GW. Jenkinson SF, et al. Among authors: butters td. J Org Chem. 2013 Aug 2;78(15):7380-97. doi: 10.1021/jo4005487. Epub 2013 Jun 5. J Org Chem. 2013. PMID: 23688199

5

An approach to 8 stereoisomers of homonojirimycin from (D)-glucose via kinetic & thermodynamic azido-γ-lactones.

Glawar AF, Jenkinson SF, Newberry SJ, Thompson AL, Nakagawa S, Yoshihara A, Akimitsu K, Izumori K, Butters TD, Kato A, Fleet GW. Glawar AF, et al. Among authors: butters td. Org Biomol Chem. 2013 Sep 25;11(40):6886-99. doi: 10.1039/c3ob41334a. Org Biomol Chem. 2013. PMID: 23963282

6

Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols.

Crabtree EV, Martínez RF, Nakagawa S, Adachi I, Butters TD, Kato A, Fleet GW, Glawar AF. Crabtree EV, et al. Among authors: butters td. Org Biomol Chem. 2014 Jun 21;12(23):3932-43. doi: 10.1039/c4ob00097h. Org Biomol Chem. 2014. PMID: 24802185

7

Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids.

Glawar AF, Martínez RF, Ayers BJ, Hollas MA, Ngo N, Nakagawa S, Kato A, Butters TD, Fleet GW, Jenkinson SF. Glawar AF, et al. Among authors: butters td. Org Biomol Chem. 2016 Nov 8;14(44):10371-10385. doi: 10.1039/c6ob01549b. Org Biomol Chem. 2016. PMID: 27735004

8

Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.

Yu CY, Asano N, Ikeda K, Wang MX, Butters TD, Wormald MR, Dwek RA, Winters AL, Nash RJ, Fleet GW. Yu CY, et al. Among authors: butters td. Chem Commun (Camb). 2004 Sep 7;(17):1936-7. doi: 10.1039/b406035k. Epub 2004 Jul 29. Chem Commun (Camb). 2004. PMID: 15340609

9

Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin.

Blériot Y, Gretzke D, Krülle TM, Butters TD, Dwek RA, Nash RJ, Asano N, Fleet GW. Blériot Y, et al. Among authors: butters td. Carbohydr Res. 2005 Dec 30;340(18):2713-8. doi: 10.1016/j.carres.2005.10.002. Epub 2005 Nov 4. Carbohydr Res. 2005. PMID: 16274755

10

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

Rountree JS, Butters TD, Wormald MR, Boomkamp SD, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GW. Rountree JS, et al. Among authors: butters td. ChemMedChem. 2009 Mar;4(3):378-92. doi: 10.1002/cmdc.200800350. ChemMedChem. 2009. PMID: 19145603

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