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Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys.
Pinkstaff J, McCullagh E, Grover A, Melton AC, Cherukuri A, Wait JC, Nguyen A, Butt MT, Trombley JL, Reed RP, Adams EL, Boyd RB, Chandra S, Henshaw J, O'Neill CA, Zanelli E, Kovalchin J. Pinkstaff J, et al. Among authors: butt mt. Toxicol Rep. 2023 Mar 1;10:357-366. doi: 10.1016/j.toxrep.2023.02.014. eCollection 2023. Toxicol Rep. 2023. PMID: 36923444 Free PMC article.
Global economic burden of unmet surgical need for appendicitis.
Reuter A, Rogge L, Monahan M, Kachapila M, Morton DG, Davies J, Vollmer S; NIHR Global Surgery Collaboration. Reuter A, et al. Br J Surg. 2022 Sep 9;109(10):995-1003. doi: 10.1093/bjs/znac195. Br J Surg. 2022. PMID: 35881506 Free PMC article.
Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB.
Ellinwood NM, Valentine BN, Hess AS, Jens JK, Snella EM, Jamil M, Hostetter SJ, Jeffery ND, Smith JD, Millman ST, Parsons RL, Butt MT, Chandra S, Egeland MT, Assis AB, Nelvagal HR, Cooper JD, Nestrasil I, Mueller BA, Labounek R, Paulson A, Prill H, Liu XY, Zhou H, Lawrence R, Crawford BE, Grover A, Cherala G, Melton AC, Cherukuri A, Vuillemenot BR, Wait JCM, O'Neill CA, Pinkstaff J, Kovalchin J, Zanelli E, McCullagh E. Ellinwood NM, et al. Among authors: butt mt. J Pharmacol Exp Ther. 2022 Sep;382(3):277-286. doi: 10.1124/jpet.122.001119. Epub 2022 Jun 18. J Pharmacol Exp Ther. 2022. PMID: 35717448 Free PMC article.
76 results