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Page 1
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fatykhova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Hönzke K, et al. Among authors: bushe j. Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35728978 Free PMC article.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics.
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J. Wyler E, et al. Among authors: bushe j. Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. Mol Ther. 2022. PMID: 35339689 Free PMC article.
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zürcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J. Rothenberger S, et al. Among authors: bushe j. Nat Biotechnol. 2022 Dec;40(12):1845-1854. doi: 10.1038/s41587-022-01382-3. Epub 2022 Jul 21. Nat Biotechnol. 2022. PMID: 35864170 Free PMC article.
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19.
Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN. Aznaourova M, et al. Among authors: bushe j. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. Proc Natl Acad Sci U S A. 2022. PMID: 35998224 Free PMC article.
The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters.
Shytaj IL, Fares M, Gallucci L, Lucic B, Tolba MM, Zimmermann L, Adler JM, Xing N, Bushe J, Gruber AD, Ambiel I, Taha Ayoub A, Cortese M, Neufeldt CJ, Stolp B, Sobhy MH, Fathy M, Zhao M, Laketa V, Diaz RS, Sutton RE, Chlanda P, Boulant S, Bartenschlager R, Stanifer ML, Fackler OT, Trimpert J, Savarino A, Lusic M. Shytaj IL, et al. Among authors: bushe j. mBio. 2022 Apr 26;13(2):e0370521. doi: 10.1128/mbio.03705-21. Epub 2022 Mar 1. mBio. 2022. PMID: 35229634 Free PMC article.
Stem cell-derived vessels-on-chip for cardiovascular disease modeling.
Marder M, Remmert C, Perschel JA, Otgonbayar M, von Toerne C, Hauck S, Bushe J, Feuchtinger A, Sheikh B, Moussus M, Meier M. Marder M, et al. Among authors: bushe j. Cell Rep. 2024 Apr 23;43(4):114008. doi: 10.1016/j.celrep.2024.114008. Epub 2024 Mar 26. Cell Rep. 2024. PMID: 38536819 Free article.
Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters.
Teixeira Alves LG, Baumgardt M, Langner C, Fischer M, Maria Adler J, Bushe J, Firsching TC, Mastrobuoni G, Grobe J, Hoenzke K, Kempa S, Gruber AD, Hocke AC, Trimpert J, Wyler E, Landthaler M. Teixeira Alves LG, et al. Among authors: bushe j. BMJ Open Respir Res. 2024 Feb 29;11(1):e001762. doi: 10.1136/bmjresp-2023-001762. BMJ Open Respir Res. 2024. PMID: 38423952 Free PMC article.
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
Nouailles G, Adler JM, Pennitz P, Peidli S, Teixeira Alves LG, Baumgardt M, Bushe J, Voss A, Langenhagen A, Langner C, Martin Vidal R, Pott F, Kazmierski J, Ebenig A, Lange MV, Mühlebach MD, Goekeri C, Simmons S, Xing N, Abdelgawad A, Herwig S, Cichon G, Niemeyer D, Drosten C, Goffinet C, Landthaler M, Blüthgen N, Wu H, Witzenrath M, Gruber AD, Praktiknjo SD, Osterrieder N, Wyler E, Kunec D, Trimpert J. Nouailles G, et al. Among authors: bushe j. Nat Microbiol. 2023 May;8(5):860-874. doi: 10.1038/s41564-023-01352-8. Epub 2023 Apr 3. Nat Microbiol. 2023. PMID: 37012419 Free PMC article.
Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice.
Weissfuss C, Wienhold SM, Bürkle M, Gaborieau B, Bushe J, Behrendt U, Bischoff R, Korf IHE, Wienecke S, Dannheim A, Ziehr H, Rohde C, Gruber AD, Ricard JD, Debarbieux L, Witzenrath M, Nouailles G. Weissfuss C, et al. Among authors: bushe j. Viruses. 2023 Jan 29;15(2):387. doi: 10.3390/v15020387. Viruses. 2023. PMID: 36851601 Free PMC article.
14 results