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Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects.
J Gen Physiol. 2024 Jan 1;156(1):e202313419. doi: 10.1085/jgp.202313419. Epub 2023 Nov 9.
J Gen Physiol. 2024.
PMID: 37943249
Free PMC article.
Novel TRPM7 inhibitors with potent anti-inflammatory effects in vivo.
Busey GW, Manjegowda MC, Huang T, Iobst WH, Naphade SS, Kennedy JA, Doyle CA, Seegren PV, Lynch KR, Desai BN.
Busey GW, et al.
bioRxiv [Preprint]. 2023 Aug 26:2023.05.22.541802. doi: 10.1101/2023.05.22.541802.
bioRxiv. 2023.
PMID: 37662207
Free PMC article.
Preprint.
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Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity.
Schappe MS, Stremska ME, Busey GW, Downs TK, Seegren PV, Mendu SK, Flegal Z, Doyle CA, Stipes EJ, Desai BN.
Schappe MS, et al. Among authors: busey gw.
Nat Commun. 2022 Jun 9;13(1):3230. doi: 10.1038/s41467-022-30959-4.
Nat Commun. 2022.
PMID: 35680919
Free PMC article.
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