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MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity.
Bosc N, Felix E, Gardner JMF, Mills J, Timmerman M, Asveld D, Rensen K, Mukherjee P, Das R, Chenu E, Besson D, Burrows JN, Duffy J, Laleu B, Guantai EM, Leach AR. Bosc N, et al. Among authors: burrows jn. ACS Med Chem Lett. 2023 Nov 20;14(12):1733-1741. doi: 10.1021/acsmedchemlett.3c00369. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116432 Free PMC article.
Fragment screening: an introduction.
Leach AR, Hann MM, Burrows JN, Griffen EJ. Leach AR, et al. Among authors: burrows jn. Mol Biosyst. 2006 Sep;2(9):430-46. doi: 10.1039/b610069b. Mol Biosyst. 2006. PMID: 17153140
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
Nchinda AT, Le Manach C, Paquet T, Gonzàlez Cabrera D, Wicht KJ, Brunschwig C, Njoroge M, Abay E, Taylor D, Lawrence N, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Lafuente-Monasterio MJ, Duffy J, Burrows J, Street LJ, Chibale K. Nchinda AT, et al. J Med Chem. 2018 May 10;61(9):4213-4227. doi: 10.1021/acs.jmedchem.8b00382. Epub 2018 Apr 27. J Med Chem. 2018. PMID: 29665687
MAIP: a web service for predicting blood-stage malaria inhibitors.
Bosc N, Felix E, Arcila R, Mendez D, Saunders MR, Green DVS, Ochoada J, Shelat AA, Martin EJ, Iyer P, Engkvist O, Verras A, Duffy J, Burrows J, Gardner JMF, Leach AR. Bosc N, et al. J Cheminform. 2021 Feb 22;13(1):13. doi: 10.1186/s13321-021-00487-2. J Cheminform. 2021. PMID: 33618772 Free PMC article.
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang W, Jayaseelan J, Katneni K, Patil R, Saunders J, Shahi SP, Chittimalla R, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Tumwebaze PK, Rosenthal PJ, Cooper RA, Aguiar ACC, Guido RVC, Pereira DB, Mittal N, Winzeler EA, Tomchick DR, Laleu B, Burrows JN, Rathod PK, Fidock DA, Charman SA, Phillips MA. Palmer MJ, et al. Among authors: burrows jn. J Med Chem. 2021 May 13;64(9):6085-6136. doi: 10.1021/acs.jmedchem.1c00173. Epub 2021 Apr 20. J Med Chem. 2021. PMID: 33876936 Free PMC article.
Actives from MMV Open Access Boxes? A suggested way forward.
Samby K, Willis PA, Burrows JN, Laleu B, Webborn PJH. Samby K, et al. Among authors: burrows jn. PLoS Pathog. 2021 Apr 22;17(4):e1009384. doi: 10.1371/journal.ppat.1009384. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33886696 Free PMC article. Review.
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362.
Lowe MA, Cardenas A, Valentin JP, Zhu Z, Abendroth J, Castro JL, Class R, Delaunois A, Fleurance R, Gerets H, Gryshkova V, King L, Lorimer DD, MacCoss M, Rowley JH, Rosseels ML, Royer L, Taylor RD, Wong M, Zaccheo O, Chavan VP, Ghule GA, Tapkir BK, Burrows JN, Duffey M, Rottmann M, Wittlin S, Angulo-Barturen I, Jiménez-Díaz MB, Striepen J, Fairhurst KJ, Yeo T, Fidock DA, Cowman AF, Favuzza P, Crespo-Fernandez B, Gamo FJ, Goldberg DE, Soldati-Favre D, Laleu B, de Haro T. Lowe MA, et al. Among authors: burrows jn. J Med Chem. 2022 Oct 27;65(20):14121-14143. doi: 10.1021/acs.jmedchem.2c01336. Epub 2022 Oct 10. J Med Chem. 2022. PMID: 36216349 Free PMC article.
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.
Walz A, Duffey M, Aljayyoussi G, Sax S, Leroy D, Besson D, Burrows JN, Cherkaoui-Rbati MH, Gobeau N, Westwood MA, Siethoff C, Gamo FJ, Mäser P, Wittlin S. Walz A, et al. Among authors: burrows jn. Pharmaceuticals (Basel). 2023 Jan 23;16(2):163. doi: 10.3390/ph16020163. Pharmaceuticals (Basel). 2023. PMID: 37009844 Free PMC article.
95 results