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IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection.
Côté SC, Burke Schinkel SC, Berthoud TK, Barros PO, Sanchez-Vidales M, Davidson AM, Crawley AM, Angel JB. Côté SC, et al. Among authors: burke schinkel sc. Eur J Immunol. 2020 Oct;50(10):1537-1549. doi: 10.1002/eji.201948453. Epub 2020 May 27. Eur J Immunol. 2020. PMID: 32390135 Free PMC article.
Soluble CD127 potentiates IL-7 activity in vivo in healthy mice.
Aloufi NA, Ali AK, Burke Schinkel SC, Molyer B, Barros PO, McBane JE, Lee SH, Angel JB. Aloufi NA, et al. Among authors: burke schinkel sc. Immun Inflamm Dis. 2021 Dec;9(4):1798-1808. doi: 10.1002/iid3.530. Epub 2021 Sep 15. Immun Inflamm Dis. 2021. PMID: 34525268 Free PMC article.