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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Maji A, et al. Among authors: burke md. Nature. 2023 Nov;623(7989):1079-1085. doi: 10.1038/s41586-023-06710-4. Epub 2023 Nov 8. Nature. 2023. PMID: 37938782 Free PMC article.
Amphotericin primarily kills yeast by simply binding ergosterol.
Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD. Gray KC, et al. Among authors: burke md. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9. doi: 10.1073/pnas.1117280109. Epub 2012 Jan 17. Proc Natl Acad Sci U S A. 2012. PMID: 22308411 Free PMC article.
Electronic tuning of site-selectivity.
Wilcock BC, Uno BE, Bromann GL, Clark MJ, Anderson TM, Burke MD. Wilcock BC, et al. Among authors: burke md. Nat Chem. 2012 Dec;4(12):996-1003. doi: 10.1038/nchem.1495. Nat Chem. 2012. PMID: 23174979 Free PMC article.
Amphotericin forms an extramembranous and fungicidal sterol sponge.
Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD. Anderson TM, et al. Among authors: burke md. Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30. Nat Chem Biol. 2014. PMID: 24681535 Free PMC article.
Nontoxic antimicrobials that evade drug resistance.
Davis SA, Vincent BM, Endo MM, Whitesell L, Marchillo K, Andes DR, Lindquist S, Burke MD. Davis SA, et al. Among authors: burke md. Nat Chem Biol. 2015 Jul;11(7):481-7. doi: 10.1038/nchembio.1821. Epub 2015 Jun 1. Nat Chem Biol. 2015. PMID: 26030729 Free PMC article.
C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.
Davis SA, Della Ripa LA, Hu L, Cioffi AG, Pogorelov TV, Rienstra CM, Burke MD. Davis SA, et al. Among authors: burke md. J Am Chem Soc. 2015 Dec 9;137(48):15102-4. doi: 10.1021/jacs.5b05766. Epub 2015 Nov 30. J Am Chem Soc. 2015. PMID: 26580003 Free PMC article.
Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers.
Della Ripa LA, Petros ZA, Cioffi AG, Piehl DW, Courtney JM, Burke MD, Rienstra CM. Della Ripa LA, et al. Among authors: burke md. Methods. 2018 Apr 1;138-139:47-53. doi: 10.1016/j.ymeth.2018.01.008. Epub 2018 Feb 21. Methods. 2018. PMID: 29366688 Free PMC article.
280 results