Burghaus R - Search Results

1

Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban.

Willmann S, Becker C, Burghaus R, Coboeken K, Edginton A, Lippert J, Siegmund HU, Thelen K, Mück W. Willmann S, et al. Among authors: burghaus r. Clin Pharmacokinet. 2014 Jan;53(1):89-102. doi: 10.1007/s40262-013-0090-5. Clin Pharmacokinet. 2014. PMID: 23912563 Free PMC article. Clinical Trial.

2

Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.

Burghaus R, Coboeken K, Gaub T, Kuepfer L, Sensse A, Siegmund HU, Weiss W, Mueck W, Lippert J. Burghaus R, et al. PLoS One. 2011 Apr 22;6(4):e17626. doi: 10.1371/journal.pone.0017626. PLoS One. 2011. PMID: 21526168 Free PMC article.

3

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions.

Thelen K, Coboeken K, Willmann S, Burghaus R, Dressman JB, Lippert J. Thelen K, et al. Among authors: burghaus r. J Pharm Sci. 2011 Dec;100(12):5324-45. doi: 10.1002/jps.22726. Epub 2011 Oct 12. J Pharm Sci. 2011. PMID: 21993815

4

Development of a physiologically based computational kidney model to describe the renal excretion of hydrophilic agents in rats.

Niederalt C, Wendl T, Kuepfer L, Claassen K, Loosen R, Willmann S, Lippert J, Schultze-Mosgau M, Winkler J, Burghaus R, Bräutigam M, Pietsch H, Lengsfeld P. Niederalt C, et al. Among authors: burghaus r. Front Physiol. 2013 Jan 24;3:494. doi: 10.3389/fphys.2012.00494. eCollection 2012. Front Physiol. 2013. PMID: 23355822 Free PMC article.

5

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban-an oral, direct Factor Xa inhibitor.

Burghaus R, Coboeken K, Gaub T, Niederalt C, Sensse A, Siegmund HU, Weiss W, Mueck W, Tanigawa T, Lippert J. Burghaus R, et al. Front Physiol. 2014 Nov 7;5:417. doi: 10.3389/fphys.2014.00417. eCollection 2014. Front Physiol. 2014. PMID: 25426077 Free PMC article.

6

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.

Krauss M, Burghaus R, Lippert J, Niemi M, Neuvonen P, Schuppert A, Willmann S, Kuepfer L, Görlitz L. Krauss M, et al. Among authors: burghaus r. In Silico Pharmacol. 2013 Apr 11;1:6. doi: 10.1186/2193-9616-1-6. eCollection 2013. In Silico Pharmacol. 2013. PMID: 25505651 Free PMC article.

7

Contribution of rivaroxaban to the international normalized ratio when switching to warfarin for anticoagulation as determined by simulation studies.

Siegmund HU, Burghaus R, Kubitza D, Coboeken K. Siegmund HU, et al. Among authors: burghaus r. Br J Clin Pharmacol. 2015 Jun;79(6):959-66. doi: 10.1111/bcp.12571. Br J Clin Pharmacol. 2015. PMID: 25510952 Free PMC article.

8

Modeling and Simulation of In Vivo Drug Effects.

Lippert J, Burghaus R, Kuepfer L, Ploeger B, Schaller S, Schmitt W, Willmann S. Lippert J, et al. Among authors: burghaus r. Handb Exp Pharmacol. 2016;232:313-29. doi: 10.1007/164_2015_21. Handb Exp Pharmacol. 2016. PMID: 26578524 Review.

9

Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation.

EFPIA MID3 Workgroup; Marshall SF, Burghaus R, Cosson V, Cheung SY, Chenel M, DellaPasqua O, Frey N, Hamrén B, Harnisch L, Ivanow F, Kerbusch T, Lippert J, Milligan PA, Rohou S, Staab A, Steimer JL, Tornøe C, Visser SA. EFPIA MID3 Workgroup, et al. Among authors: burghaus r. CPT Pharmacometrics Syst Pharmacol. 2016 Mar;5(3):93-122. doi: 10.1002/psp4.12049. Epub 2016 Mar 14. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27069774 Free PMC article.

10

Comment on model-based meta-analysis to evaluate optimal doses of direct oral factor Xa inhibitors in atrial fibrillation patients.

Willmann S, Zhang L, Mayer H, Siegmund HU, Tanigawa T, Kaneko M, Peters G, Weitz JI, Berkowitz SD, Burghaus R. Willmann S, et al. Among authors: burghaus r. Blood Adv. 2018 Nov 27;2(22):3193-3195. doi: 10.1182/bloodadvances.2018027078. Blood Adv. 2018. PMID: 30482761 Free PMC article. No abstract available.

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