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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Bourne CR, Bunce RA, Bourne PC, Berlin KD, Barrow EW, Barrow WW. Bourne CR, et al. Among authors: bunce ra. Antimicrob Agents Chemother. 2009 Jul;53(7):3065-73. doi: 10.1128/AAC.01666-08. Epub 2009 Apr 13. Antimicrob Agents Chemother. 2009. PMID: 19364848 Free PMC article.
Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines.
Nammalwar B, Bourne CR, Bunce RA, Wakeham N, Bourne PC, Ramnarayan K, Mylvaganam S, Berlin KD, Barrow EW, Barrow WW. Nammalwar B, et al. Among authors: bunce ra. ChemMedChem. 2012 Nov;7(11):1974-82. doi: 10.1002/cmdc.201200291. Epub 2012 Aug 28. ChemMedChem. 2012. PMID: 22930550 Free PMC article.
Approaches to Iodinated Derivatives of Vanillin and Isovanillin.
Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Nammalwar B, et al. Among authors: bunce ra. Org Prep Proced Int. 2012;44(2):146-152. doi: 10.1080/00304948.2012.643700. Org Prep Proced Int. 2012. PMID: 23805008 Free PMC article. No abstract available.
55 results