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AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation.
Gélinas R, Mailleux F, Dontaine J, Bultot L, Demeulder B, Ginion A, Daskalopoulos EP, Esfahani H, Dubois-Deruy E, Lauzier B, Gauthier C, Olson AK, Bouchard B, Des Rosiers C, Viollet B, Sakamoto K, Balligand JL, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L. Gélinas R, et al. Among authors: bultot l. Nat Commun. 2018 Jan 25;9(1):374. doi: 10.1038/s41467-017-02795-4. Nat Commun. 2018. PMID: 29371602 Free PMC article.
Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.
Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Hunter RW, et al. Among authors: bultot l. Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014. Chem Biol. 2014. PMID: 25036776 Free PMC article.
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.
Bultot L, Jensen TE, Lai YC, Madsen AL, Collodet C, Kviklyte S, Deak M, Yavari A, Foretz M, Ghaffari S, Bellahcene M, Ashrafian H, Rider MH, Richter EA, Sakamoto K. Bultot L, et al. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719. doi: 10.1152/ajpendo.00237.2016. Epub 2016 Aug 30. Am J Physiol Endocrinol Metab. 2016. PMID: 27577855 Free PMC article.
AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.
Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R. Theret M, et al. Among authors: bultot l. EMBO J. 2017 Jul 3;36(13):1946-1962. doi: 10.15252/embj.201695273. Epub 2017 May 17. EMBO J. 2017. PMID: 28515121 Free PMC article.
Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake.
Renguet E, Ginion A, Gélinas R, Bultot L, Auquier J, Robillard Frayne I, Daneault C, Vanoverschelde JL, Des Rosiers C, Hue L, Horman S, Beauloye C, Bertrand L. Renguet E, et al. Among authors: bultot l. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H432-H445. doi: 10.1152/ajpheart.00738.2016. Epub 2017 Jun 23. Am J Physiol Heart Circ Physiol. 2017. PMID: 28646031 Free article.
26 results