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Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli.
Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. Hockley JR, et al. Among authors: bulmer dc. Pain. 2014 Oct;155(10):1962-75. doi: 10.1016/j.pain.2014.06.015. Epub 2014 Jun 24. Pain. 2014. PMID: 24972070 Free PMC article.
The voltage-gated sodium channel NaV 1.9 in visceral pain.
Hockley JR, Winchester WJ, Bulmer DC. Hockley JR, et al. Among authors: bulmer dc. Neurogastroenterol Motil. 2016 Mar;28(3):316-26. doi: 10.1111/nmo.12698. Epub 2015 Oct 14. Neurogastroenterol Motil. 2016. PMID: 26462871 Review.
P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.
Hockley JR, Tranter MM, McGuire C, Boundouki G, Cibert-Goton V, Thaha MA, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, Bulmer DC. Hockley JR, et al. Among authors: bulmer dc. J Neurosci. 2016 Feb 24;36(8):2364-76. doi: 10.1523/JNEUROSCI.3369-15.2016. J Neurosci. 2016. PMID: 26911685 Free PMC article.
Ex vivo study of human visceral nociceptors.
McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. McGuire C, et al. Among authors: bulmer dc. Gut. 2018 Jan;67(1):86-96. doi: 10.1136/gutjnl-2016-311629. Epub 2016 Sep 21. Gut. 2018. PMID: 27654583 Free PMC article.
Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.
Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC, Cendán CM, McMurray G. Hockley JR, et al. Among authors: bulmer dc. J Physiol. 2017 Apr 15;595(8):2661-2679. doi: 10.1113/JP272837. Epub 2017 Mar 1. J Physiol. 2017. PMID: 28105664 Free PMC article.
Single-cell RNAseq reveals seven classes of colonic sensory neuron.
Hockley JRF, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ESJ. Hockley JRF, et al. Among authors: bulmer dc. Gut. 2019 Apr;68(4):633-644. doi: 10.1136/gutjnl-2017-315631. Epub 2018 Feb 26. Gut. 2019. PMID: 29483303 Free PMC article.
5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.
Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N. Bautzova T, et al. Among authors: bulmer dc. Sci Signal. 2018 Dec 18;11(561):eaal2171. doi: 10.1126/scisignal.aal2171. Sci Signal. 2018. PMID: 30563864 Free PMC article.
44 results