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Physiologic facet capsule stretch can induce pain & upregulate matrix metalloproteinase-3 in the dorsal root ganglia when preceded by a physiological mechanical or nonpainful chemical exposure.
Singh S, Kartha S, Bulka BA, Stiansen NS, Winkelstein BA. Singh S, et al. Among authors: bulka ba. Clin Biomech (Bristol, Avon). 2019 Apr;64:122-130. doi: 10.1016/j.clinbiomech.2018.01.009. Epub 2018 Jan 31. Clin Biomech (Bristol, Avon). 2019. PMID: 29523370 Free PMC article.