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Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells.
Bulcaen M, Kortleven P, Liu RB, Maule G, Dreano E, Kelly M, Ensinck MM, Thierie S, Smits M, Ciciani M, Hatton A, Chevalier B, Ramalho AS, Casadevall I Solvas X, Debyser Z, Vermeulen F, Gijsbers R, Sermet-Gaudelus I, Cereseto A, Carlon MS. Bulcaen M, et al. Cell Rep Med. 2024 Apr 24:101544. doi: 10.1016/j.xcrm.2024.101544. Online ahead of print. Cell Rep Med. 2024. PMID: 38697102 Free article.
Genetic surgery for a cystic fibrosis-causing splicing mutation.
Bulcaen M, Carlon MS. Bulcaen M, et al. Mol Ther Methods Clin Dev. 2024 Jan 2;32(1):101177. doi: 10.1016/j.omtm.2023.101177. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38261927 Free PMC article. No abstract available.
Nanoblades allow high-level genome editing in murine and human organoids.
Tiroille V, Krug A, Bokobza E, Kahi M, Bulcaen M, Ensinck MM, Geurts MH, Hendriks D, Vermeulen F, Larbret F, Gutierrez-Guerrero A, Chen Y, Van Zundert I, Rocha S, Rios AC, Medaer L, Gijsbers R, Mangeot PE, Clevers H, Carlon MS, Bost F, Verhoeyen E. Tiroille V, et al. Among authors: bulcaen m. Mol Ther Nucleic Acids. 2023 Jun 8;33:57-74. doi: 10.1016/j.omtn.2023.06.004. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37435135 Free PMC article.
Point-of-care therapeutic drug monitoring of adalimumab by integrating a FO-SPR biosensor in a self-powered microfluidic cartridge.
Qu JH, Ordutowski H, Van Tricht C, Verbruggen R, Barcenas Gallardo A, Bulcaen M, Ciwinska M, Gutierrez Cisneros C, Devriese C, Guluzade S, Janssens X, Kornblum S, Lu Y, Marolt N, Nanjappan C, Rutten E, Vanhauwaert E, Geukens N, Thomas D, Dal Dosso F, Safdar S, Spasic D, Lammertyn J. Qu JH, et al. Among authors: bulcaen m. Biosens Bioelectron. 2022 Jun 15;206:114125. doi: 10.1016/j.bios.2022.114125. Epub 2022 Mar 2. Biosens Bioelectron. 2022. PMID: 35255315
Rewriting CFTR to cure cystic fibrosis.
Maule G, Ensinck M, Bulcaen M, Carlon MS. Maule G, et al. Among authors: bulcaen m. Prog Mol Biol Transl Sci. 2021;182:185-224. doi: 10.1016/bs.pmbts.2020.12.018. Epub 2021 Jan 28. Prog Mol Biol Transl Sci. 2021. PMID: 34175042 Review.