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Proteomic approaches to study ubiquitinomics.
Sahu I, Zhu H, Buhrlage SJ, Marto JA. Sahu I, et al. Among authors: buhrlage sj. Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194940. doi: 10.1016/j.bbagrm.2023.194940. Epub 2023 Apr 29. Biochim Biophys Acta Gene Regul Mech. 2023. PMID: 37121501 Free PMC article. Review.
Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes.
Ficarro SB, Browne CM, Card JD, Alexander WM, Zhang T, Park E, McNally R, Dhe-Paganon S, Seo HS, Lamberto I, Eck MJ, Buhrlage SJ, Gray NS, Marto JA. Ficarro SB, et al. Among authors: buhrlage sj. Anal Chem. 2016 Dec 20;88(24):12248-12254. doi: 10.1021/acs.analchem.6b03394. Epub 2016 Nov 30. Anal Chem. 2016. PMID: 28193034
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Schauer NJ, Liu X, Magin RS, Doherty LM, Chan WC, Ficarro SB, Hu W, Roberts RM, Iacob RE, Stolte B, Giacomelli AO, Perera S, McKay K, Boswell SA, Weisberg EL, Ray A, Chauhan D, Dhe-Paganon S, Anderson KC, Griffin JD, Li J, Hahn WC, Sorger PK, Engen JR, Stegmaier K, Marto JA, Buhrlage SJ. Schauer NJ, et al. Among authors: buhrlage sj. Sci Rep. 2020 Mar 24;10(1):5324. doi: 10.1038/s41598-020-62076-x. Sci Rep. 2020. PMID: 32210275 Free PMC article.
Identification and validation of selective deubiquitinase inhibitors.
Varca AC, Casalena D, Chan WC, Hu B, Magin RS, Roberts RM, Liu X, Zhu H, Seo HS, Dhe-Paganon S, Marto JA, Auld D, Buhrlage SJ. Varca AC, et al. Among authors: buhrlage sj. Cell Chem Biol. 2021 Dec 16;28(12):1758-1771.e13. doi: 10.1016/j.chembiol.2021.05.012. Epub 2021 Jun 14. Cell Chem Biol. 2021. PMID: 34129829 Free PMC article.
Chemoproteomic methods for covalent drug discovery.
Chan WC, Sharifzadeh S, Buhrlage SJ, Marto JA. Chan WC, et al. Among authors: buhrlage sj. Chem Soc Rev. 2021 Aug 2;50(15):8361-8381. doi: 10.1039/d1cs00231g. Chem Soc Rev. 2021. PMID: 34143170 Free PMC article. Review.
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.
Yang J, Weisberg EL, Liu X, Magin RS, Chan WC, Hu B, Schauer NJ, Zhang S, Lamberto I, Doherty L, Meng C, Sattler M, Cabal-Hierro L, Winer E, Stone R, Marto JA, Griffin JD, Buhrlage SJ. Yang J, et al. Among authors: buhrlage sj. Leukemia. 2022 Jan;36(1):210-220. doi: 10.1038/s41375-021-01336-9. Epub 2021 Jul 29. Leukemia. 2022. PMID: 34326465
DUB to the rescue.
Teh WP, Zhu H, Marto JA, Buhrlage SJ. Teh WP, et al. Among authors: buhrlage sj. Mol Cell. 2022 Apr 21;82(8):1411-1413. doi: 10.1016/j.molcel.2022.03.039. Mol Cell. 2022. PMID: 35452613 Free article.
On-Chip Preconcentration Microchip Capillary Electrophoresis Based CE-PRM-LIVE for High-Throughput Selectivity Profiling of Deubiquitinase Inhibitors.
Zhu H, Mellors JS, Chan WC, Thompson JW, Ficarro SB, Tavares I, Bratt AS, Decker J, Krause M, Kruppa G, Buhrlage SJ, Marto JA. Zhu H, et al. Among authors: buhrlage sj. Anal Chem. 2022 Jul 12;94(27):9508-9513. doi: 10.1021/acs.analchem.2c01337. Epub 2022 Jun 21. Anal Chem. 2022. PMID: 35729701 Free PMC article.
Accelerating inhibitor discovery for deubiquitinating enzymes.
Chan WC, Liu X, Magin RS, Girardi NM, Ficarro SB, Hu W, Tarazona Guzman MI, Starnbach CA, Felix A, Adelmant G, Varca AC, Hu B, Bratt AS, DaSilva E, Schauer NJ, Jaen Maisonet I, Dolen EK, Ayala AX, Marto JA, Buhrlage SJ. Chan WC, et al. Among authors: buhrlage sj. Nat Commun. 2023 Feb 8;14(1):686. doi: 10.1038/s41467-023-36246-0. Nat Commun. 2023. PMID: 36754960 Free PMC article.
65 results