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Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.
Ladrière L, Igoillo-Esteve M, Cunha DA, Brion JP, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Ladrière L, et al. Among authors: bugliani m. J Clin Endocrinol Metab. 2010 Mar;95(3):1442-9. doi: 10.1210/jc.2009-2322. Epub 2010 Jan 15. J Clin Endocrinol Metab. 2010. PMID: 20080856
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.
Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladrière L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL. Grieco FA, et al. Among authors: bugliani m. Diabetes. 2017 Jan;66(1):100-112. doi: 10.2337/db16-0592. Epub 2016 Oct 13. Diabetes. 2017. PMID: 27737950 Free PMC article.
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Cunha DA, et al. Among authors: bugliani m. J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11. J Biol Chem. 2017. PMID: 28698383 Free PMC article.
DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes.
Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P. Bugliani M, et al. Mol Cell Endocrinol. 2018 Sep 15;473:186-193. doi: 10.1016/j.mce.2018.01.019. Epub 2018 Feb 1. Mol Cell Endocrinol. 2018. PMID: 29409957
Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction.
Bugliani M, Liechti R, Cheon H, Suleiman M, Marselli L, Kirkpatrick C, Filipponi F, Boggi U, Xenarios I, Syed F, Ladriere L, Wollheim C, Lee MS, Marchetti P. Bugliani M, et al. Mol Cell Endocrinol. 2013 Mar 10;367(1-2):1-10. doi: 10.1016/j.mce.2012.12.001. Epub 2012 Dec 12. Mol Cell Endocrinol. 2013. PMID: 23246353
110 results