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Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum †.
Diukendjieva A, Zaharieva MM, Mori M, Alov P, Tsakovska I, Pencheva T, Najdenski H, Křen V, Felici C, Bufalieri F, Di Marcotullio L, Botta B, Botta M, Pajeva I. Diukendjieva A, et al. Among authors: bufalieri f. Antioxidants (Basel). 2020 May 5;9(5):384. doi: 10.3390/antiox9050384. Antioxidants (Basel). 2020. PMID: 32380762 Free PMC article.
Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.
Quaranta R, Pelullo M, Zema S, Nardozza F, Checquolo S, Lauer DM, Bufalieri F, Palermo R, Felli MP, Vacca A, Talora C, Di Marcotullio L, Screpanti I, Bellavia D. Quaranta R, et al. Among authors: bufalieri f. Cell Death Dis. 2017 Jul 20;8(7):e2942. doi: 10.1038/cddis.2017.326. Cell Death Dis. 2017. PMID: 28726779 Free PMC article.
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L. Infante P, et al. Among authors: bufalieri f. Nat Commun. 2018 Mar 7;9(1):976. doi: 10.1038/s41467-018-03339-0. Nat Commun. 2018. PMID: 29515120 Free PMC article.
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth.
Lospinoso Severini L, Quaglio D, Basili I, Ghirga F, Bufalieri F, Caimano M, Balducci S, Moretti M, Romeo I, Loricchio E, Maroder M, Botta B, Mori M, Infante P, Di Marcotullio L. Lospinoso Severini L, et al. Among authors: bufalieri f. Cancers (Basel). 2019 Oct 9;11(10):1518. doi: 10.3390/cancers11101518. Cancers (Basel). 2019. PMID: 31601026 Free PMC article.
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma.
Lospinoso Severini L, Ghirga F, Bufalieri F, Quaglio D, Infante P, Di Marcotullio L. Lospinoso Severini L, et al. Among authors: bufalieri f. Expert Opin Ther Targets. 2020 Nov;24(11):1159-1181. doi: 10.1080/14728222.2020.1823967. Epub 2020 Sep 29. Expert Opin Ther Targets. 2020. PMID: 32990091 Review.
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma.
Infante P, Malfanti A, Quaglio D, Balducci S, De Martin S, Bufalieri F, Mastrotto F, Basili I, Garofalo M, Lospinoso Severini L, Mori M, Manni I, Moretti M, Nicoletti C, Piaggio G, Caliceti P, Botta B, Ghirga F, Salmaso S, Di Marcotullio L. Infante P, et al. Among authors: bufalieri f. Cancer Lett. 2021 Feb 28;499:220-231. doi: 10.1016/j.canlet.2020.11.028. Epub 2020 Nov 26. Cancer Lett. 2021. PMID: 33249196 Free article.
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