Buehler PW - Search Results

1

Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.

Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Schaer CA, et al. Among authors: buehler pw. Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. doi: 10.1164/rccm.201510-2058OC. Am J Respir Crit Care Med. 2016. PMID: 26694989 Free PMC article.

2

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity.

Deuel JW, Vallelian F, Schaer CA, Puglia M, Buehler PW, Schaer DJ. Deuel JW, et al. Among authors: buehler pw. Free Radic Biol Med. 2015 Dec;89:931-43. doi: 10.1016/j.freeradbiomed.2015.09.016. Epub 2015 Oct 22. Free Radic Biol Med. 2015. PMID: 26475040 Free article.

3

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ. Schaer CA, et al. Among authors: buehler pw. BMC Biotechnol. 2018 Mar 15;18(1):15. doi: 10.1186/s12896-018-0424-3. BMC Biotechnol. 2018. PMID: 29544494 Free PMC article.

4

Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.

Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ. Hugelshofer M, et al. Among authors: buehler pw. J Clin Invest. 2019 Dec 2;129(12):5219-5235. doi: 10.1172/JCI130630. J Clin Invest. 2019. PMID: 31454333 Free PMC article.

5

Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response.

Deuel JW, Schaer CA, Boretti FS, Opitz L, Garcia-Rubio I, Baek JH, Spahn DR, Buehler PW, Schaer DJ. Deuel JW, et al. Among authors: buehler pw. Cell Death Dis. 2016 Jan 21;7(1):e2064. doi: 10.1038/cddis.2015.392. Cell Death Dis. 2016. PMID: 26794659 Free PMC article.

6

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.

Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, Cipollo JF, Jia Y, Mikolajczyk M, Boretti FS, Schoedon G, Alayash AI, Schaer DJ. Buehler PW, et al. Blood. 2009 Mar 12;113(11):2578-86. doi: 10.1182/blood-2008-08-174466. Epub 2009 Jan 8. Blood. 2009. PMID: 19131549 Free article.

7

Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase.

Widmer CC, Pereira CP, Gehrig P, Vallelian F, Schoedon G, Buehler PW, Schaer DJ. Widmer CC, et al. Among authors: buehler pw. Antioxid Redox Signal. 2010 Feb;12(2):185-98. doi: 10.1089/ars.2009.2826. Antioxid Redox Signal. 2010. PMID: 19702440 Free article.

8

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW. Baek JH, et al. Among authors: buehler pw. J Clin Invest. 2012 Apr;122(4):1444-58. doi: 10.1172/JCI59770. Epub 2012 Mar 26. J Clin Invest. 2012. PMID: 22446185 Free PMC article.

9

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Schaer DJ, et al. Among authors: buehler pw. Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Blood. 2013. PMID: 23264591 Free PMC article. Review.

10

Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ. Lipiski M, et al. Among authors: buehler pw. Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33. doi: 10.1089/ars.2012.5089. Epub 2013 Mar 28. Antioxid Redox Signal. 2013. PMID: 23418677 Free PMC article.

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