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Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.
Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni I, Park JK, Martella A, van der Wel T, Soethoudt M, Jiang M, Wendel TJ, Janssen APA, Bakker AT, Donovan CM, Castillo LI, Florea BI, Wat J, van den Hurk H, Wittwer M, Grether U, Holmes A, van Boeckel CAA, Hankemeier T, Cravatt BF, Buczynski MW, Hill MN, Pacher P, Lichtman AH, van der Stelt M. Mock ED, et al. Among authors: buczynski mw. Nat Chem Biol. 2020 Jun;16(6):667-675. doi: 10.1038/s41589-020-0528-7. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393901 Free PMC article.
Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake.
Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Serrano A, et al. Among authors: buczynski mw. Neuropsychopharmacology. 2018 Aug;43(9):1840-1850. doi: 10.1038/s41386-018-0055-3. Epub 2018 Apr 5. Neuropsychopharmacology. 2018. PMID: 29748627 Free PMC article.
Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure.
Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Parsons LH. Buczynski MW, et al. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1086-91. doi: 10.1073/pnas.1522672113. Epub 2016 Jan 11. Proc Natl Acad Sci U S A. 2016. PMID: 26755579 Free PMC article.
Druggable Targets in Endocannabinoid Signaling.
Gregus AM, Buczynski MW. Gregus AM, et al. Among authors: buczynski mw. Adv Exp Med Biol. 2020;1274:177-201. doi: 10.1007/978-3-030-50621-6_8. Adv Exp Med Biol. 2020. PMID: 32894511 Free PMC article. Review.
Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility.
Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis IY, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH. Natividad LA, et al. Among authors: buczynski mw. Addict Biol. 2018 Sep;23(5):1117-1129. doi: 10.1111/adb.12568. Epub 2017 Sep 22. Addict Biol. 2018. PMID: 28940879 Free PMC article.
42 results