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1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.
Franchini S, Sorbi C, Linciano P, Carnevale G, Tait A, Ronsisvalle S, Buccioni M, Del Bello F, Cilia A, Pirona L, Denora N, Iacobazzi RM, Brasili L. Franchini S, et al. Among authors: buccioni m. Eur J Med Chem. 2019 Aug 15;176:310-325. doi: 10.1016/j.ejmech.2019.05.024. Epub 2019 May 11. Eur J Med Chem. 2019. PMID: 31112892
Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates.
Dei S, Bellucci C, Buccioni M, Ferraroni M, Gualtieri F, Guandalini L, Manetti D, Matucci R, Romanelli MN, Scapecchi S, Teodori E. Dei S, et al. Among authors: buccioni m. Bioorg Med Chem. 2003 Jul 17;11(14):3153-64. doi: 10.1016/s0968-0896(03)00236-0. Bioorg Med Chem. 2003. PMID: 12818678
1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands.
Tait A, Luppi A, Franchini S, Preziosi E, Parenti C, Buccioni M, Marucci G, Leonardi A, Poggesi E, Brasili L. Tait A, et al. Among authors: buccioni m. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1185-8. doi: 10.1016/j.bmcl.2004.12.004. Bioorg Med Chem Lett. 2005. PMID: 15686938
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.
Quaglia W, Santoni G, Pigini M, Piergentili A, Gentili F, Buccioni M, Mosca M, Lucciarini R, Amantini C, Nabissi MI, Ballarini P, Poggesi E, Leonardi A, Giannella M. Quaglia W, et al. Among authors: buccioni m. J Med Chem. 2005 Dec 1;48(24):7750-63. doi: 10.1021/jm0580398. J Med Chem. 2005. PMID: 16302814
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
Scapecchi S, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Martelli C, Manetti D, Martini E, Marucci G, Nesi M, Romanelli MN, Teodori E, Gualtieri F. Scapecchi S, et al. Among authors: buccioni m. J Med Chem. 2006 Mar 23;49(6):1925-31. doi: 10.1021/jm0510878. J Med Chem. 2006. PMID: 16539379
Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.
Piergentili A, Quaglia W, Giannella M, Del Bello F, Bruni B, Buccioni M, Carrieri A, Ciattini S. Piergentili A, et al. Among authors: buccioni m. Bioorg Med Chem. 2007 Jan 15;15(2):886-96. doi: 10.1016/j.bmc.2006.10.040. Epub 2006 Oct 21. Bioorg Med Chem. 2007. PMID: 17084634
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Martini E, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E. Dei S, et al. Among authors: buccioni m. J Med Chem. 2007 Mar 22;50(6):1409-13. doi: 10.1021/jm061374r. Epub 2007 Feb 17. J Med Chem. 2007. PMID: 17305327
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