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Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
Bubenik M, Mader P, Mochirian P, Vallée F, Clark J, Truchon JF, Perryman AL, Pau V, Kurinov I, Zahn KE, Leclaire ME, Papp R, Mathieu MC, Hamel M, Duffy NM, Godbout C, Casas-Selves M, Falgueyret JP, Baruah PS, Nicolas O, Stocco R, Poirier H, Martino G, Fortin AB, Roulston A, Chefson A, Dorich S, St-Onge M, Patel P, Pellerin C, Ciblat S, Pinter T, Barabé F, El Bakkouri M, Parikh P, Gervais C, Sfeir A, Mamane Y, Morris SJ, Black WC, Sicheri F, Gallant M. Bubenik M, et al. J Med Chem. 2022 Oct 13;65(19):13198-13215. doi: 10.1021/acs.jmedchem.2c00998. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126059 Free PMC article.
Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.
Henderson JA, Bilimoria D, Bubenik M, Cadilhac C, Cottrell KM, Dietrich E, Denis F, Ewing N, Falardeau G, Giroux S, Grey R Jr, L'Heureux L, Liu B, Mani N, Morris M, Nicolas O, Pereira OZ, Poisson C, Govinda Rao B, Reddy TJ, Selliah S, Shawgo RS, Vaillancourt L, Wang J, Yannopoulos CG, Chauret N, Berlioz-Seux F, Chan LC, Das SK, Grillot AL, Bennani YL, Maxwell JP. Henderson JA, et al. Among authors: bubenik m. Bioorg Med Chem Lett. 2015 Feb 15;25(4):944-7. doi: 10.1016/j.bmcl.2014.12.045. Epub 2014 Dec 20. Bioorg Med Chem Lett. 2015. PMID: 25577041
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.
Henderson JA, Bilimoria D, Bubenik M, Cadilhac C, Cottrell KM, Denis F, Dietrich E, Ewing N, Falardeau G, Giroux S, L'Heureux L, Liu B, Mani N, Morris M, Nicolas O, Pereira OZ, Poisson C, Reddy TJ, Selliah S, Shawgo RS, Vaillancourt L, Wang J, Xu J, Chauret N, Berlioz-Seux F, Chan LC, Das SK, Grillot AL, Bennani YL, Maxwell JP. Henderson JA, et al. Among authors: bubenik m. Bioorg Med Chem Lett. 2015 Feb 15;25(4):948-51. doi: 10.1016/j.bmcl.2014.12.042. Epub 2014 Dec 22. Bioorg Med Chem Lett. 2015. PMID: 25577039
Thiophene-based vitronectin receptor antagonists.
Bubenik M, Meerovitch K, Bergeron F, Attardo G, Chan L. Bubenik M, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):503-6. doi: 10.1016/s0960-894x(02)00942-3. Bioorg Med Chem Lett. 2003. PMID: 12565960
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions.
Kemnitzer W, Jiang S, Wang Y, Kasibhatla S, Crogan-Grundy C, Bubenik M, Labrecque D, Denis R, Lamothe S, Attardo G, Gourdeau H, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: bubenik m. Bioorg Med Chem Lett. 2008 Jan 15;18(2):603-7. doi: 10.1016/j.bmcl.2007.11.078. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18077161
Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis.
Fajkus P, Adámik M, Nelson ADL, Kilar AM, Franek M, Bubeník M, Frydrychová RČ, Votavová A, Sýkorová E, Fajkus J, Peška V. Fajkus P, et al. Among authors: bubenik m. Nucleic Acids Res. 2023 Jan 11;51(1):420-433. doi: 10.1093/nar/gkac1202. Nucleic Acids Res. 2023. PMID: 36546771 Free PMC article.
Telomeric DNA sequences in beetle taxa vary with species richness.
Prušáková D, Peska V, Pekár S, Bubeník M, Čížek L, Bezděk A, Čapková Frydrychová R. Prušáková D, et al. Among authors: bubenik m. Sci Rep. 2021 Jun 25;11(1):13319. doi: 10.1038/s41598-021-92705-y. Sci Rep. 2021. PMID: 34172809 Free PMC article.
11 results