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966 results

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Page 1
Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion.
Hu X, Yasuda T, Yasuda-Yosihara N, Yonemura A, Umemoto T, Nakachi Y, Yamashita K, Semba T, Arima K, Uchihara T, Nishimura A, Bu L, Fu L, Wei F, Zhang J, Tong Y, Wang H, Iwamoto K, Fukuda T, Nakagawa H, Taniguchi K, Miyamoto Y, Baba H, Ishimoto T. Hu X, et al. Among authors: bu l. JHEP Rep. 2023 Aug 23;5(12):100892. doi: 10.1016/j.jhepr.2023.100892. eCollection 2023 Dec. JHEP Rep. 2023. PMID: 37942226 Free PMC article.
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Arima K, Ohmuraya M, Miyake K, Koiwa M, Uchihara T, Izumi D, Gao F, Yonemura A, Bu L, Okabe H, Imai K, Hashimoto D, Baba Y, Chikamoto A, Yamashita YI, Furukawa T, Araki K, Baba H, Ishimoto T. Arima K, et al. Among authors: bu l. Oncogene. 2019 Feb;38(8):1211-1224. doi: 10.1038/s41388-018-0510-y. Epub 2018 Sep 24. Oncogene. 2019. PMID: 30250298
Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination.
Yasuda T, Koiwa M, Yonemura A, Miyake K, Kariya R, Kubota S, Yokomizo-Nakano T, Yasuda-Yoshihara N, Uchihara T, Itoyama R, Bu L, Fu L, Arima K, Izumi D, Iwagami S, Eto K, Iwatsuki M, Baba Y, Yoshida N, Ohguchi H, Okada S, Matsusaki K, Sashida G, Takahashi A, Tan P, Baba H, Ishimoto T. Yasuda T, et al. Among authors: bu l. Cell Rep. 2021 Feb 23;34(8):108779. doi: 10.1016/j.celrep.2021.108779. Cell Rep. 2021. PMID: 33626356 Free article.
Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.
Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T. Fu L, et al. Among authors: bu l. Gastric Cancer. 2022 May;25(3):542-557. doi: 10.1007/s10120-022-01283-z. Epub 2022 Feb 15. Gastric Cancer. 2022. PMID: 35166958
Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer.
Bu L, Yonemura A, Yasuda-Yoshihara N, Uchihara T, Ismagulov G, Takasugi S, Yasuda T, Okamoto Y, Kitamura F, Akiyama T, Arima K, Itoyama R, Zhang J, Fu L, Hu X, Wei F, Arima Y, Moroishi T, Nishiyama K, Sheng G, Mukunoki T, Otani J, Baba H, Ishimoto T. Bu L, et al. Cancer Sci. 2022 Oct;113(10):3579-3592. doi: 10.1111/cas.15495. Epub 2022 Aug 23. Cancer Sci. 2022. PMID: 35848891 Free PMC article.
Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer.
Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O, Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto T. Kitamura F, et al. Among authors: bu l. JCI Insight. 2023 Oct 23;8(20):e163022. doi: 10.1172/jci.insight.163022. JCI Insight. 2023. PMID: 37733442 Free PMC article.
Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1β from activated macrophages leads to poor prognosis in pancreatic cancer.
Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, Uchihara T, Ogata Y, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Yamashita YI, Baba H, Ishimoto T. Arima K, et al. Among authors: bu l. Cancer Sci. 2018 Feb;109(2):462-470. doi: 10.1111/cas.13467. Epub 2018 Jan 27. Cancer Sci. 2018. PMID: 29224225 Free PMC article.
966 results