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Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer.
Zech HB, Berger J, Mansour WY, Nordquist L, von Bargen CM, Bußmann L, Oetting A, Christiansen S, Möckelmann N, Böttcher A, Busch CJ, Petersen C, Betz C, Rothkamm K, Kriegs M, Köcher S, Rieckmann T. Zech HB, et al. Among authors: bussmann l. Radiother Oncol. 2022 Mar;168:138-146. doi: 10.1016/j.radonc.2022.01.017. Epub 2022 Jan 29. Radiother Oncol. 2022. PMID: 35093407
Analyzing expression and phosphorylation of the EGF receptor in HNSCC.
Kriegs M, Clauditz TS, Hoffer K, Bartels J, Buhs S, Gerull H, Zech HB, Bußmann L, Struve N, Rieckmann T, Petersen C, Betz CS, Rothkamm K, Nollau P, Münscher A. Kriegs M, et al. Among authors: bussmann l. Sci Rep. 2019 Sep 19;9(1):13564. doi: 10.1038/s41598-019-49885-5. Sci Rep. 2019. PMID: 31537844 Free PMC article.
EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma.
Struve N, Binder ZA, Stead LF, Brend T, Bagley SJ, Faulkner C, Ott L, Müller-Goebel J, Weik AS, Hoffer K, Krug L, Rieckmann T, Bußmann L, Henze M, Morrissette JJD, Kurian KM, Schüller U, Petersen C, Rothkamm K, O Rourke DM, Short SC, Kriegs M. Struve N, et al. Among authors: bussmann l. Oncogene. 2020 Apr;39(15):3041-3055. doi: 10.1038/s41388-020-1208-5. Epub 2020 Feb 17. Oncogene. 2020. PMID: 32066879 Free PMC article.
Comparative effectiveness trial of transoral head and neck surgery followed by adjuvant radio(chemo)therapy versus primary radiochemotherapy for oropharyngeal cancer (TopROC).
Bußmann L, Laban S, Wittekindt C, Stromberger C, Tribius S, Möckelmann N, Böttcher A, Betz CS, Klussmann JP, Budach V, Muenscher A, Busch CJ. Bußmann L, et al. BMC Cancer. 2020 Jul 29;20(1):701. doi: 10.1186/s12885-020-07127-2. BMC Cancer. 2020. PMID: 32727416 Free PMC article.
Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src family kinases as prognostic markers and potential targets.
Bußmann L, Hoffer K, von Bargen CM, Droste C, Lange T, Kemmling J, Schröder-Schwarz J, Vu AT, Akingunsade L, Nollau P, Rangarajan S, de Wijn R, Oetting A, Müller C, Böckelmann LC, Zech HB, Berger JC, Möckelmann N, Busch CJ, Böttcher A, Gatzemeier F, Klinghammer K, Simnica D, Binder M, Struve N, Rieckmann T, Schumacher U, Clauditz TS, Betz CS, Petersen C, Rothkamm K, Münscher A, Kriegs M. Bußmann L, et al. Int J Cancer. 2021 Sep 1;149(5):1166-1180. doi: 10.1002/ijc.33606. Epub 2021 May 7. Int J Cancer. 2021. PMID: 33890294 Free article.
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