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Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair.
Wang M, Li W, Tomimatsu N, Yu CH, Ji JH, Alejo S, Witus SR, Alimbetov D, Fitzgerald O, Wu B, Wang Q, Huang Y, Gan Y, Dong F, Kwon Y, Sareddy GR, Curiel TJ, Habib AA, Hromas R, Dos Santos Passos C, Yao T, Ivanov DN, Brzovic PS, Burma S, Klevit RE, Zhao W. Wang M, et al. Among authors: brzovic ps. Mol Cell. 2023 Oct 19;83(20):3679-3691.e8. doi: 10.1016/j.molcel.2023.09.015. Epub 2023 Oct 4. Mol Cell. 2023. PMID: 37797621
Bacterial mimicry of eukaryotic HECT ubiquitin ligation.
Franklin TG, Brzovic PS, Pruneda JN. Franklin TG, et al. Among authors: brzovic ps. bioRxiv [Preprint]. 2023 Jun 5:2023.06.05.543783. doi: 10.1101/2023.06.05.543783. bioRxiv. 2023. PMID: 37333152 Free PMC article. Preprint.
Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context.
Radkov A, Sapiro AL, Flores S, Henderson C, Saunders H, Kim R, Massa S, Thompson S, Mateusiak C, Biboy J, Zhao Z, Starita LM, Hatleberg WL, Vollmer W, Russell AB, Simorre JP, Anthony-Cahill S, Brzovic P, Hayes B, Chou S. Radkov A, et al. Among authors: brzovic p. Elife. 2022 Jun 28;11:e79796. doi: 10.7554/eLife.79796. Elife. 2022. PMID: 35762582 Free PMC article.
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain.
Reiter KH, Zelter A, Janowska MK, Riffle M, Shulman N, MacLean BX, Tamura K, Chambers MC, MacCoss MJ, Davis TN, Guttman M, Brzovic PS, Klevit RE. Reiter KH, et al. Among authors: brzovic ps. Structure. 2022 Sep 1;30(9):1269-1284.e6. doi: 10.1016/j.str.2022.05.017. Epub 2022 Jun 17. Structure. 2022. PMID: 35716664 Free PMC article.
BRCA1/BARD1 is a nucleosome reader and writer.
Witus SR, Zhao W, Brzovic PS, Klevit RE. Witus SR, et al. Among authors: brzovic ps. Trends Biochem Sci. 2022 Jul;47(7):582-595. doi: 10.1016/j.tibs.2022.03.001. Epub 2022 Mar 26. Trends Biochem Sci. 2022. PMID: 35351360 Free PMC article. Review.
63 results