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Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+RORγt+/IL-10+FoxP3+ ratio in CD4+ T cells.
Gudmundsdottir AB, Omarsdottir S, Brynjolfsdottir A, Paulsen BS, Olafsdottir ES, Freysdottir J. Gudmundsdottir AB, et al. Among authors: brynjolfsdottir a. Immunol Lett. 2015 Feb;163(2):157-62. doi: 10.1016/j.imlet.2014.11.008. Epub 2014 Dec 9. Immunol Lett. 2015. PMID: 25499021
Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.
Gudmundsdottir AB, Brynjolfsdottir A, Olafsdottir ES, Hardardottir I, Freysdottir J. Gudmundsdottir AB, et al. Among authors: brynjolfsdottir a. Int Immunopharmacol. 2019 Apr;69:328-336. doi: 10.1016/j.intimp.2019.01.044. Epub 2019 Feb 15. Int Immunopharmacol. 2019. PMID: 30772700
Blue Lagoon Algae Improve Uneven Skin Pigmentation: Results from in vitro Studies and from a Monocentric, Randomized, Double-Blind, Vehicle-Controlled, Split-Face Study.
Grether-Beck S, Marini A, Jaenicke T, Brenden H, Felsner I, Aue N, Brynjolfsdottir A, Krutmann J. Grether-Beck S, et al. Among authors: brynjolfsdottir a. Skin Pharmacol Physiol. 2022;35(2):77-86. doi: 10.1159/000518781. Epub 2021 Jul 30. Skin Pharmacol Physiol. 2022. PMID: 34348349 Clinical Trial.
Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing.
Grether-Beck S, Mühlberg K, Brenden H, Felsner I, Brynjólfsdóttir A, Einarsson S, Krutmann J. Grether-Beck S, et al. Among authors: brynjolfsdottir a. Exp Dermatol. 2008 Sep;17(9):771-9. doi: 10.1111/j.1600-0625.2007.00693.x. Epub 2008 Feb 28. Exp Dermatol. 2008. PMID: 18312388