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CYP17 inhibitors for prostate cancer therapy.
Vasaitis TS, Bruno RD, Njar VC. Vasaitis TS, et al. Among authors: bruno rd. J Steroid Biochem Mol Biol. 2011 May;125(1-2):23-31. doi: 10.1016/j.jsbmb.2010.11.005. Epub 2010 Nov 17. J Steroid Biochem Mol Biol. 2011. PMID: 21092758 Free PMC article. Review.
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
Bruno RD, Vasaitis TS, Gediya LK, Purushottamachar P, Godbole AM, Ates-Alagoz Z, Brodie AM, Njar VC. Bruno RD, et al. Steroids. 2011 Nov;76(12):1268-79. doi: 10.1016/j.steroids.2011.06.002. Epub 2011 Jun 24. Steroids. 2011. PMID: 21729712 Free PMC article.
VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.
Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC. Godbole AM, et al. Among authors: bruno rd. Eur J Pharmacol. 2014 Jul 5;734:98-104. doi: 10.1016/j.ejphar.2014.04.004. Epub 2014 Apr 12. Eur J Pharmacol. 2014. PMID: 24726842 Free PMC article.
34 results